Ibuprofen lysine
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MedKoo CAT#: 573231

CAS#: 57469-77-9

Description: Ibuprofen lysine is a non-steroidal anti-inflammatory drug (NSAID). The lysine suspension of Ibuprofen may act more quickly and effectively than base Ibuprofen.


Chemical Structure

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Ibuprofen lysine
CAS# 57469-77-9

Theoretical Analysis

MedKoo Cat#: 573231
Name: Ibuprofen lysine
CAS#: 57469-77-9
Chemical Formula: C19H32N2O4
Exact Mass: 352.2362
Molecular Weight: 352.48
Elemental Analysis: C, 64.74; H, 9.15; N, 7.95; O, 18.16

Price and Availability

Size Price Availability Quantity
1.0g USD 305.0 2 Weeks
10.0g USD 1450.0 2 Weeks
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Synonym: Arflamin, Ibuprofen lysinate, Ibuprofen lysine, NeoProfen, Saren

IUPAC/Chemical Name: L-Lysine mono(4-isobutyl-alpha-methylbenzeneacetate)

InChi Key: IHHXIUAEPKVVII-ZSCHJXSPSA-N

InChi Code: 1S/C13H18O2.C6H14N2O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;7-4-2-1-3-5(8)6(9)10/h4-7,9-10H,8H2,1-3H3,(H,14,15);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1

SMILES Code: CC(C)Cc1ccc(cc1)C(C)C(=O)O.C(CCN)C[C@@H](C(=O)O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 352.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: García-Arieta A, Ferrero-Cafiero JM, Puntes M, Gich I, Morales-Alcelay S, Tarré M, Font X, Antonijoan RM. Impact of Chiral Bioanalytical Methods on the Bioequivalence of Ibuprofen Products Containing Ibuprofen Lysinate and Ibuprofen Base. Chirality. 2016 May;28(5):429-33. doi: 10.1002/chir.22598. Epub 2016 Apr 20. PubMed PMID: 27094918.

2: Ferrero-Cafiero JM, Gich I, Puntes M, Martínez J, Ballester MR, Coimbra J, Mathison Y, Tarré M, Font X, Antonijoan RM. Ibuprofen lysinate, quicker and less variable: relative bioavailability compared to ibuprofen base in a pediatric suspension dosage form. Int J Clin Pharmacol Ther. 2015 Nov;53(11):972-9. doi: 10.5414/CP202368. PubMed PMID: 26249766.

3: Vladiskovic C, Masciocchi N. Reversibly changing a painkiller structure: a hot topic for a cold case--ibuprofen lysine salt. J Pharm Biomed Anal. 2015 Mar 25;107:394-402. doi: 10.1016/j.jpba.2015.01.028. Epub 2015 Jan 22. PubMed PMID: 25659531.