Lyso-PAF C-16
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530786

CAS#: 52691-62-0

Description: Lyso-PAF C-16, also known as Lyso-gepc is a lipid compound, and a biologically inactive precursor of platelet activating factor. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.

Chemical Structure

img
Lyso-PAF C-16
CAS# 52691-62-0
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530786
Name: Lyso-PAF C-16
CAS#: 52691-62-0
Chemical Formula: C24H52NO6P
Exact Mass: 481.35
Molecular Weight: 481.655
Elemental Analysis: C, 59.85; H, 10.88; N, 2.91; O, 19.93; P, 6.43

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
25mg USD 650 2 Weeks
Bulk inquiry

Synonym: Lyso-PAF C-16; Lyso-gepc; Lyso-platelet activating factor C16; LPC O-16:0;

IUPAC/Chemical Name: 3,5,9-Trioxa-4-phosphapentacosan-1-aminium, 4,7-dihydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-

InChi Key: VLBPIWYTPAXCFJ-XMMPIXPASA-N

InChi Code: InChI=1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1

SMILES Code: CCCCCCCCCCCCCCCCOC[C@@H](O)COP(OCC[N+](C)(C)C)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Lyso-PAF C-16, also known as Lyso-gepc is a lipid compound, and a biologically inactive precursor of platelet activating factor.
In vitro activity: Exogenous PAF C-16 inhibited the growth of M. smegmatis inside phagocytic cells of monocytic cell line, THP-1; this effect was partially blocked by PAF receptor antagonists, suggesting the involvement of PAF receptor-mediated signaling pathways. Reference: Front Microbiol. 2020 Jun 10;11:1046. https://pubmed.ncbi.nlm.nih.gov/32587578/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 10.0 20.76
DMSO 10.0 20.76
Ethanol 10.0 20.76
PBS (pH 7.2) 10.0 20.76
Water 20.0 41.52

Preparing Stock Solutions

The following data is based on the product molecular weight 481.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Dissecting the Mechanism of Intracellular Mycobacterium smegmatis Growth Inhibition by Platelet Activating Factor C-16. Front Microbiol. 2020 Jun 10;11:1046. doi: 10.3389/fmicb.2020.01046. PMID: 32587578; PMCID: PMC7297918. 2. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. Front Microbiol. 2018 Sep 11;9:1903. doi: 10.3389/fmicb.2018.01903. PMID: 30258409; PMCID: PMC6143801.
In vitro protocol: 1. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Dissecting the Mechanism of Intracellular Mycobacterium smegmatis Growth Inhibition by Platelet Activating Factor C-16. Front Microbiol. 2020 Jun 10;11:1046. doi: 10.3389/fmicb.2020.01046. PMID: 32587578; PMCID: PMC7297918. 2. Riaz MS, Kaur A, Shwayat SN, Behboudi S, Kishore U, Pathan AA. Direct Growth Inhibitory Effect of Platelet Activating Factor C-16 and Its Structural Analogs on Mycobacteria. Front Microbiol. 2018 Sep 11;9:1903. doi: 10.3389/fmicb.2018.01903. PMID: 30258409; PMCID: PMC6143801.
In vivo protocol: TBD

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li Y, Hou M, Wang JG, Wang T, Wan J, Jiao BH, Lin ZF. Changes of lymph metabolites in a rat model of sepsis induced by cecal ligation and puncture. J Trauma Acute Care Surg. 2012 Dec;73(6):1545-52. doi: 10.1097/TA.0b013e31826fc9e7. PubMed PMID: 23147180.

2: Qian CG, Lee TC, Snyder F. Metabolism of platelet activating factor (PAF) and related ether lipids by neonatal rat myocytes. J Lipid Mediat. 1989 Mar-Apr;1(2):113-23. PubMed PMID: 2519887.

3: Mickelson JK, Simpson PJ, Lucchesi BR. Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. J Mol Cell Cardiol. 1988 Jun;20(6):547-61. PubMed PMID: 3216407.