Gemcabene

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564683

CAS#: 183293-82-5

Description: Gemcabene is a lipid altering agent which lowers low-density lipoprotein cholesterol (LDL-C) and decreases triglycerides. Gemcabene increases high density lipoprotein (HDL) cholesterol levels and HDL particle size.


Chemical Structure

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Gemcabene
CAS# 183293-82-5

Theoretical Analysis

MedKoo Cat#: 564683
Name: Gemcabene
CAS#: 183293-82-5
Chemical Formula: C16H30O5
Exact Mass: 302.21
Molecular Weight: 302.410
Elemental Analysis: C, 63.55; H, 10.00; O, 26.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PD72953; PD 72953; PD-72953; Gemcabene

IUPAC/Chemical Name: 6,6'-Oxybis(2,2-dimethylhexanoic acid)

InChi Key: SDMBRCRVFFHJKR-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)

SMILES Code: O=C(O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 302.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471. doi: 10.3389/fphar.2018.00471. eCollection 2018. PubMed PMID: 29867478; PubMed Central PMCID: PMC5958179.

2: Oniciu DC, Hashiguchi T, Shibazaki Y, Bisgaier CL. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13(5):e0194568. doi: 10.1371/journal.pone.0194568. eCollection 2018. PubMed PMID: 29847555; PubMed Central PMCID: PMC5976190.

3: Srivastava RAK, Cornicelli JA, Markham B, Bisgaier CL. Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism. Mol Cell Biochem. 2018 Dec;449(1-2):167-183. doi: 10.1007/s11010-018-3353-5. Epub 2018 Apr 11. PubMed PMID: 29644527; PubMed Central PMCID: PMC6223808.

4: Bisgaier CL, Oniciu DC, Srivastava RAK. Comparative Evaluation of Gemcabene and Peroxisome Proliferator-Activated Receptor Ligands in Transcriptional Assays of Peroxisome Proliferator-Activated Receptors: Implication for the Treatment of Hyperlipidemia and Cardiovascular Disease. J Cardiovasc Pharmacol. 2018 Jul;72(1):3-10. doi: 10.1097/FJC.0000000000000580. PubMed PMID: 29621036; PubMed Central PMCID: PMC6039382.