Lysyl-tyrosyl-lysine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530299

CAS#: 35193-18-1

Description: Lysyl-tyrosyl-lysine is a bioactive chemical.

Chemical Structure

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Lysyl-tyrosyl-lysine
CAS# 35193-18-1
Instruction

Theoretical Analysis

MedKoo Cat#: 530299
Name: Lysyl-tyrosyl-lysine
CAS#: 35193-18-1
Chemical Formula: C21H35N5O5
Exact Mass: 437.26
Molecular Weight: 437.541
Elemental Analysis: C, 57.65; H, 8.06; N, 16.01; O, 18.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lysyl-tyrosyl-lysine

IUPAC/Chemical Name: L-Lysine, N2-(N-L-lysyl-L-tyrosyl)-

InChi Key: WINFHLHJTRGLCV-BZSNNMDCSA-N

InChi Code: InChI=1S/C21H35N5O5/c22-11-3-1-5-16(24)19(28)26-18(13-14-7-9-15(27)10-8-14)20(29)25-17(21(30)31)6-2-4-12-23/h7-10,16-18,27H,1-6,11-13,22-24H2,(H,25,29)(H,26,28)(H,30,31)/t16-,17-,18-/m0/s1

SMILES Code: NCCCC[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CCCCN)N)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 437.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Prell JS, O'Brien JT, Holm AI, Leib RD, Donald WA, Williams ER. Electron capture by a hydrated gaseous peptide: effects of water on fragmentation and molecular survival. J Am Chem Soc. 2008 Sep 24;130(38):12680-9. doi: 10.1021/ja8022434. Epub 2008 Aug 30. PubMed PMID: 18761457; PubMed Central PMCID: PMC2673717.

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3: Cheng CT, Lo V, Chen J, Chen WC, Lin CY, Lin HC, Yang CH, Sheh L. Synthesis and DNA nicking studies of a novel cyclic peptide: cyclo[Lys-Trp-Lys-Ahx-]. Bioorg Med Chem. 2001 Jun;9(6):1493-8. PubMed PMID: 11408167.

4: Kato-Toma Y, Ishiguro M. Reaction of Lys-Tyr-Lys triad mimics with benzylpenicillin: insight into the role of Tyr150 in class C beta-lactamase. Bioorg Med Chem Lett. 2001 May 7;11(9):1161-4. PubMed PMID: 11354367.

5: Limoli CL, Wu CC, Milligan JR, Ward JF. Photochemical production of uracil quantified in bromodeoxyuridine-substituted SV40 DNA by uracil DNA glycosylase and a lysyl-tyrosyl-lysine tripeptide. Mutagenesis. 1997 Nov;12(6):443-7. PubMed PMID: 9412998.

6: Barthwal R, Kukreti S, Mujeeb A. A 500 MHz proton NMR study of interaction of tripeptides Lys-Tyr-Lys and Lys-Phe-Lys with deoxydinucleotide d-CpG. Indian J Biochem Biophys. 1992 Oct;29(5):394-401. PubMed PMID: 1289228.

7: Barthwal R, Mujeeb A, Kukreti S, Gupta A, Govil G. A 500 MHz proton NMR study of stacking interactions: binding of tripeptide Lys-Tyr-Lys to tetradeoxynucleotide d-GpCpGpC. J Mol Recognit. 1991 Mar-Jun;4(2-3):45-52. PubMed PMID: 1810346.

8: Favaudon V. Radiation-induced crosslinking between poly(deoxyadenylic-deoxythymidylic acid) and tripeptides containing aromatic residues. Int J Radiat Biol. 1989 Mar;55(3):353-64. PubMed PMID: 2564033.