Carnostatine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564673

CAS#: NONE

Description: Carnostatine is a potent and selective carnosinase (CN1) inhibitor.


Chemical Structure

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Carnostatine
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 564673
Name: Carnostatine
CAS#: NONE
Chemical Formula: C10H16N4O4
Exact Mass: 256.12
Molecular Weight: 256.260
Elemental Analysis: C, 46.87; H, 6.29; N, 21.86; O, 24.97

Price and Availability

Size Price Availability Quantity
25mg USD 1000 2 Weeks
100mg USD 2100 2 Weeks
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Synonym: SAN-9812; SAN 9812; SAN9812; Carnostatine

IUPAC/Chemical Name: ((S)-4-amino-2-hydroxybutanoyl)-L-histidine

InChi Key: GQHVUCIIWBBKOY-YUMQZZPRSA-N

InChi Code: InChI=1S/C10H16N4O4/c11-2-1-8(15)9(16)14-7(10(17)18)3-6-4-12-5-13-6/h4-5,7-8,15H,1-3,11H2,(H,12,13)(H,14,16)(H,17,18)/t7-,8-/m0/s1

SMILES Code: O=C(O)[C@H](CC1=CNC=N1)NC([C@@H](O)CCN)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Biological target: Carnostatine hydrochloride (SAN9812 hydrochloride) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1.
In vitro activity: Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 µM, i.e., close to the Km of 190 µM. Reference: Amino Acids. 2019 Jan;51(1):7-16. https://dx.doi.org/10.1007/s00726-018-2601-z
In vivo activity: Subcutaneous administration of 30 mg/kg Carnostatine (SAN9812) leads to a sustained reduction in circulating CN1 activity in human CN1 transgenic (TG) mice. Simultaneous administration of Carnosine and Carnostatine increases carnosine levels in plasma and kidney by up to 100-fold compared to treatment-naïve CN1-overexpressing mice. Reference: Amino Acids. 2019 Jan;51(1):7-16. https://dx.doi.org/10.1007/s00726-018-2601-z

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Water 250.0 854.06

Preparing Stock Solutions

The following data is based on the product molecular weight 256.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol: 1. Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2019 Jan;51(1):7-16. doi: 10.1007/s00726-018-2601-z. Epub 2018 Jun 20. PMID: 29922921.
In vivo protocol: 1. Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2019 Jan;51(1):7-16. doi: 10.1007/s00726-018-2601-z. Epub 2018 Jun 20. PMID: 29922921.

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1: Qiu J, Hauske SJ, Zhang S, Rodriguez-Niño A, Albrecht T, Pastene DO, van den Born J, van Goor H, Ruf S, Kohlmann M, Teufel M, Krämer BK, Hammes HP, Peters V, Yard BA, Kannt A. Identification and characterisation of carnostatine (SAN9812), a potent and selective carnosinase (CN1) inhibitor with in vivo activity. Amino Acids. 2018 Jun 20. doi: 10.1007/s00726-018-2601-z. [Epub ahead of print] PubMed PMID: 29922921.