NVP-BHS345

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564652

CAS#: NONE

Description: NVP-BHS345 is a dual inhibitor of TORC1 and TORC2.


Price and Availability

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NVP-BHS345 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564652
Name: NVP-BHS345
CAS#: NONE
Chemical Formula: C25H20N6O
Exact Mass: 420.1699
Molecular Weight: 420.48
Elemental Analysis: C, 71.41; H, 4.79; N, 19.99; O, 3.80


Synonym: NVPBHS345; NVP BHS345; NVPBHS 345; NVP-BHS345

IUPAC/Chemical Name: 2-Methyl-2-(4-(3-methyl-2-oxo-8-(pyrimidin-5-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

InChi Key: WFCPNAZSGVZANE-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H20N6O/c1-25(2,14-26)18-5-7-19(8-6-18)31-23-20-10-16(17-11-27-15-28-12-17)4-9-21(20)29-13-22(23)30(3)24(31)32/h4-13,15H,1-3H3

SMILES Code: CC(C1=CC=C(N(C2=C3C=NC4=CC=C(C5=CN=CN=C5)C=C24)C(N3C)=O)C=C1)(C)C#N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R. Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways. J Biol Chem. 2015 Jun 12;290(24):14963-78. doi: 10.1074/jbc.M114.627794. Epub 2015 Apr 16. PubMed PMID: 25882841; PubMed Central PMCID: PMC4463442.