OSU-2S Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564643

CAS#: 1351056-65-9 (free base)

Description: OSU-2S Hydrochloride is a FTY720 derivative which lacks immunosuppressive properties, but exhibits strong anti-tumour activity in several haematological and solid tumour models.

Chemical Structure

OSU-2S Hydrochloride
CAS# 1351056-65-9 (free base)

Theoretical Analysis

MedKoo Cat#: 564643
Name: OSU-2S Hydrochloride
CAS#: 1351056-65-9 (free base)
Chemical Formula: C21H38ClNO2
Exact Mass: 371.2591
Molecular Weight: 371.99
Elemental Analysis: C, 67.81; H, 10.30; Cl, 9.53; N, 3.77; O, 8.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1351056-65-9 (free base)    

Synonym: OSU2S Hydrochloride; OSU 2S Hydrochloride; OSU-2S Hydrochloride; OSU-2S HCl; OSU2S HCl; OSU 2S HCl

IUPAC/Chemical Name: (S)-2-Amino-2-(4-{(6-methylheptyl)-oxy} phenethyl)pentan-1-ol Hydrochloride


InChi Code: InChI=1S/C21H37NO2.ClH/c1-4-14-21(22,17-23)15-13-19-9-11-20(12-10-19)24-16-7-5-6-8-18(2)3;/h9-12,18,23H,4-8,13-17,22H2,1-3H3;1H/t21-;/m0./s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 371.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mani R, Chiang CL, Frissora FW, Yan R, Mo X, Baskar S, Rader C, Klisovic R, Phelps MA, Chen CS, Lee RJ, Byrd JC, Baiocchi R, Lee LJ, Muthusamy N. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo. Exp Hematol. 2015 Sep;43(9):770-4.e2. doi: 10.1016/j.exphem.2015.04.008. Epub 2015 Apr 29. PubMed PMID: 25937048.

2: Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Yu L, Flynn J, Jones J, Andritsos L, Baskar S, Rader C, Phelps MA, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia. Leukemia. 2015 Feb;29(2):346-55. doi: 10.1038/leu.2014.199. Epub 2014 Jun 20. PubMed PMID: 24947019; PubMed Central PMCID: PMC4272672.

3: Mao Y, Wang J, Zhao Y, Yan R, Li H, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N, Phelps MA. Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2014 Sep;98:160-5. doi: 10.1016/j.jpba.2014.05.022. Epub 2014 May 23. PubMed PMID: 24927402; PubMed Central PMCID: PMC4180035.

4: Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology. 2011 Jun;53(6):1943-58. doi: 10.1002/hep.24293. Epub 2011 May 2. PubMed PMID: 21391227; PubMed Central PMCID: PMC3103615.