IBE-667

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564624

CAS#: NONE

Description: IBE-667 is an activator of LFA-1-ICAM-1 binding.

Chemical Structure

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IBE-667
CAS# NONE
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 564624
Name: IBE-667
CAS#: NONE
Chemical Formula: C25H25N5O2
Exact Mass: 427.2008
Molecular Weight: 427.51
Elemental Analysis: C, 70.24; H, 5.89; N, 16.38; O, 7.48

Size Price Shipping out time Quantity
Inquire bulk and customized quantity
Pricing updated 2021-03-04. Prices are subject to change without notice.

IBE-667 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: IBE667; IBE 667; IBE-667

IUPAC/Chemical Name: N-(3-Aminopropyl)-4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzamide

InChi Key: CGHZINICBUGRGZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25N5O2/c1-27-24(31)18-11-13-20(14-12-18)30-22-6-3-2-5-21(22)23(29-30)17-7-9-19(10-8-17)25(32)28-16-4-15-26/h2-3,5-14H,4,15-16,26H2,1H3,(H,27,31)(H,28,32)

SMILES Code: O=C(NCCCN)C1=CC=C(C2=NN(C3=CC=C(C(NC)=O)C=C3)C4=C2C=CC=C4)C=C1

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 427.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Abdullahi M, Olotu FA, Soliman ME. Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation. Biotechnol Lett. 2017 Dec;39(12):1843-1851. doi: 10.1007/s10529-017-2432-0. Epub 2017 Sep 16. PubMed PMID: 28918491.

2: Hintersteiner M, Kallen J, Schmied M, Graf C, Jung T, Mudd G, Shave S, Gstach H, Auer M. Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. Angew Chem Int Ed Engl. 2014 Apr 22;53(17):4322-6. doi: 10.1002/anie.201310240. Epub 2014 Apr 1. PubMed PMID: 24692345; PubMed Central PMCID: PMC4314669.

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IBE-667