OSU-T315 (1,5-regioisomer)
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564620

CAS#: 1333146-24-9

Description: OSU-T315 (1,5-regioisomer) is a potent and specific integrin-linked kinase (ILK) inhibitor which inhibits PDK2 function in the AKT pathway activation, showing a specific mechanism of abrogating the AKT pathway and inhibition of BCR activity in the leukemic cell. OSU-T315 also acts as a selective inhibitor of biofilm formation.


Chemical Structure

img
OSU-T315 (1,5-regioisomer)
CAS# 1333146-24-9

Theoretical Analysis

MedKoo Cat#: 564620
Name: OSU-T315 (1,5-regioisomer)
CAS#: 1333146-24-9
Chemical Formula: C30H30F3N5O
Exact Mass: 533.2402
Molecular Weight: 533.6
Elemental Analysis: C, 67.53; H, 5.67; F, 10.68; N, 13.13; O, 3.00

Price and Availability

Size Price Availability Quantity
5.0mg USD 400.0 2 Weeks
10.0mg USD 750.0 2 Weeks
Bulk inquiry

Synonym: ILK inhibitor 22(1,5); T315(1,5); OSU-T315 (1,5-regioisomer); OSUT315; OSU T315; OSU-T315; CPD 22; CPD22; CPD-22

IUPAC/Chemical Name: N-Methyl-3-[1-(4-piperazin-1-yl-phenyl)-5-(4'-trifluoromethyl-biphenyl-4-yl)-1H-pyrazol-3-yl]-propionamide

InChi Key: GHBUPSVATJKTRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39)

SMILES Code: O=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 533.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Van Belle K, Herman J, Waer M, Sprangers B, Louat T. OSU-T315 as an Interesting Lead Molecule for Novel B Cell-Specific Therapeutics. J Immunol Res. 2018 Sep 12;2018:2505818. doi: 10.1155/2018/2505818. eCollection 2018. PubMed PMID: 30276218; PubMed Central PMCID: PMC6157143.

2: Mercado-Pimentel ME, Igarashi S, Dunn AM, Behbahani M, Miller C, Read CM, Jacob A. The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation. Austin J Med Oncol. 2016;3(1). pii: 1025. Epub 2016 Apr 21. PubMed PMID: 27642646; PubMed Central PMCID: PMC5024787.

3: Robak T, Smolewski P. Novel target to kill CLL. Blood. 2015 Jan 8;125(2):211-2. doi: 10.1182/blood-2014-10-606582. PubMed PMID: 25573966.

4: Liu TM, Ling Y, Woyach JA, Beckwith K, Yeh YY, Hertlein E, Zhang X, Lehman A, Awan F, Jones JA, Andritsos LA, Maddocks K, MacMurray J, Salunke SB, Chen CS, Phelps MA, Byrd JC, Johnson AJ. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. doi: 10.1182/blood-2014-06-583518. Epub 2014 Oct 7. PubMed PMID: 25293770; PubMed Central PMCID: PMC4287637.