WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564574
CAS#: 71555-14-1
Description: ZMC2 is a potent iron chelator and antiproliferative agent which exhibits zinc metallochaperone activity and enhanced sensitivity in p53-R175H cell lines.
MedKoo Cat#: 564574
Name: ZMC2
CAS#: 71555-14-1
Chemical Formula: C10H14N4S
Exact Mass: 222.0939
Molecular Weight: 222.31
Elemental Analysis: C, 54.03; H, 6.35; N, 25.20; S, 14.42
This product is not in stock, which may be available by custom synthesis.
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Synonym: NSC-319725; NSC 319725; NSC319725; Thiosemicarbazone R; ZMC-2; ZMC 2; ZMC2
IUPAC/Chemical Name: 1,1-Dimethyl-3-[(E)-1-pyridin-2-ylethylideneamino]thiourea
InChi Key: ZMZIYBQONAEPNV-XYOKQWHBSA-N
InChi Code: InChI=1S/C10H14N4S/c1-8(9-6-4-5-7-11-9)12-13-10(15)14(2)3/h4-7H,1-3H3,(H,13,15)/b12-8+
SMILES Code: S=C(N/N=C(C1=NC=CC=C1)\C)N(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 222.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Yu X, Blanden A, Tsang AT, Zaman S, Liu Y, Gilleran J, Bencivenga AF, Kimball SD, Loh SN, Carpizo DR. Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53. Mol Pharmacol. 2017 Jun;91(6):567-575. doi: 10.1124/mol.116.107409. Epub 2017 Mar 20. PubMed PMID: 28320780; PubMed Central PMCID: PMC5438133.
