4-CPPC
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564573

CAS#: 29553-70-6

Description: 4-CPPC is the first reversible and selective small molecule inhibitor of the pro-inflammatory protein macrophage migration inhibitory factor-2 (a.k.a. MIF-2 or D-DT).


Chemical Structure

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4-CPPC
CAS# 29553-70-6

Theoretical Analysis

MedKoo Cat#: 564573
Name: 4-CPPC
CAS#: 29553-70-6
Chemical Formula: C14H9NO6
Exact Mass: 287.043
Molecular Weight: 287.23
Elemental Analysis: C, 58.54; H, 3.16; N, 4.88; O, 33.42

Price and Availability

Size Price Availability Quantity
5.0mg USD 330.0 2 Weeks
10.0mg USD 545.0 2 Weeks
25.0mg USD 985.0 2 Weeks
50.0mg USD 1510.0 2 Weeks
100.0mg USD 2500.0 2 Weeks
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Synonym: 4CPPC; 4 CPPC; 4-CPPC

IUPAC/Chemical Name: 4-(3-Carboxyphenyl)-2,5-pyridinedicarboxylic acid

InChi Key: NBVHLJGGHJLTGM-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21)

SMILES Code: O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 287.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pantouris G, Bucala R, Lolis EJ. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57(26):3599-3605. doi: 10.1021/acs.biochem.8b00344. Epub 2018 Jun 12. PubMed PMID: 29847104; PubMed Central PMCID: PMC6123015.

4-CPPC

5.0mg / USD 330.0