Carlinoside

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564530

CAS#: 59952-97-5

Description: Carlinoside is a natural stimulator of bilirubin-UGT activity through Nrf2 gene expression, reducing hepatic bilirubin accumulation.

Chemical Structure

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Carlinoside
CAS# 59952-97-5
Instruction

Theoretical Analysis

MedKoo Cat#: 564530
Name: Carlinoside
CAS#: 59952-97-5
Chemical Formula: C26H28O15
Exact Mass: 580.14
Molecular Weight: 580.500
Elemental Analysis: C, 53.80; H, 4.86; O, 41.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Carlinoside

IUPAC/Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-8-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]chromen-4-one

InChi Key: XBGYTZHKGMCEGE-VYUBKLCTSA-N

InChi Code: InChI=1S/C26H28O15/c27-5-13-18(33)21(36)23(38)26(41-13)15-19(34)14-10(30)4-12(7-1-2-8(28)9(29)3-7)40-24(14)16(20(15)35)25-22(37)17(32)11(31)6-39-25/h1-4,11,13,17-18,21-23,25-29,31-38H,5-6H2/t11-,13+,17-,18+,21-,22+,23+,25-,26-/m0/s1

SMILES Code: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C(O)=C([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(O)=C3[C@@H]5OC[C@H](O)[C@H](O)[C@H]5O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 580.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Das S, Teja KC, Mukherjee S, Seal S, Sah RK, Duary B, Kim KH, Bhattacharya SS. Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles. Environ Res. 2018 Feb;161:512-523. doi: 10.1016/j.envres.2017.11.054. PubMed PMID: 29223776.

2: Das S, Hussain N, Gogoi B, Buragohain AK, Bhattacharya SS. Vermicompost and farmyard manure improves food quality, antioxidant and antibacterial potential of Cajanus cajan (L. Mill sp.) leaves. J Sci Food Agric. 2017 Feb;97(3):956-966. doi: 10.1002/jsfa.7820. Epub 2016 Jun 28. PubMed PMID: 27226361.

3: Costa G, Ferreira JP, Vitorino C, Pina ME, Sousa JJ, Figueiredo IV, Batista MT. Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents. J Ethnopharmacol. 2016 Feb 3;178:222-8. doi: 10.1016/j.jep.2015.12.016. Epub 2015 Dec 17. PubMed PMID: 26702504.

4: Proliac A, Raynaud J. [Presence of carlinoside or 6-C-beta-D-glucopyranosyl-8-C-alpha-L arabinopyranosylluteoline in Catananche caerulea (author's transl)]. Planta Med. 1977 Aug;32(1):68-70. French. PubMed PMID: 905416.

5: Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Pal BC, Bhattacharya S, Rao PG, Barua NC, Bordoloi M, Bhattacharya S. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Biochem Pharmacol. 2011 Nov 1;82(9):1186-97. doi: 10.1016/j.bcp.2011.07.069. Epub 2011 Jul 27. PubMed PMID: 21801714.