WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564515
Description: P217564 is a second-generation active site-targeted covalent irreversible inhibitor of USP7.
MedKoo Cat#: 564515
Chemical Formula: C16H12Cl2N2O5S2
Exact Mass: 445.9565
Molecular Weight: 447.3
Elemental Analysis: C, 42.96; H, 2.70; Cl, 15.85; N, 6.26; O, 17.88; S, 14.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: P-217564; P 217564; P217564
IUPAC/Chemical Name: Methyl (E)-4-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophene-2-carboxamido)but-2-enoate
InChi Key: IXFIKHBITULBSK-ZZXKWVIFSA-N
InChi Code: InChI=1S/C16H12Cl2N2O5S2/c1-25-13(21)6-3-7-19-15(22)12-8-10(20(23)24)16(27-12)26-11-5-2-4-9(17)14(11)18/h2-6,8H,7H2,1H3,(H,19,22)/b6-3+
SMILES Code: O=C(OC)/C=C/CNC(C1=CC([N+]([O-])=O)=C(SC2=CC=CC(Cl)=C2Cl)S1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 447.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S. Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017. PubMed PMID: 29236775; PubMed Central PMCID: PMC5728538.