WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564509
CAS#: NONE
Description: OMDM-188 is a potent diglyceride lipase (DGL) inhibitor which inhibits collagen-induced p38(MAPK) phosphorylation, but does not inhibit arachidonic acid-induced aggregation or TxA2 synthesis.
MedKoo Cat#: 564509
Name: OMDM-188
CAS#: NONE
Chemical Formula: C29H53NO5
Exact Mass: 495.3924
Molecular Weight: 495.75
Elemental Analysis: C, 70.26; H, 10.78; N, 2.83; O, 16.14
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: OMDM188; OMDM 188; OMDM-188
IUPAC/Chemical Name: N-Formyl-l-isoleucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
InChi Key: CBHKWVNFZKJLIS-IRGGMKSGSA-N
InChi Code: InChI=1S/C29H53NO5/c1-5-8-10-12-13-14-15-16-17-19-24(34-29(33)27(30-22-31)23(4)7-3)21-26-25(28(32)35-26)20-18-11-9-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t23-,24-,25-,26-,27-/m0/s1
SMILES Code: CC[C@H](C)[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)CCCCCCCCCCC)=O)NC=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 495.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Singh PK, Markwick R, Lu L, Howell FV, Williams G, Doherty P. Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta. Biochemistry. 2016 May 17;55(19):2713-21. doi: 10.1021/acs.biochem.6b00221. Epub 2016 May 4. PubMed PMID: 27115711.
2: Bashashati M, Nasser Y, Keenan CM, Ho W, Piscitelli F, Nalli M, Mackie K, Storr MA, Di Marzo V, Sharkey KA. Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. Br J Pharmacol. 2015 Jun;172(12):3099-111. doi: 10.1111/bph.13114. Epub 2015 Apr 23. PubMed PMID: 25684407; PubMed Central PMCID: PMC4459026.
3: Jackson EC, Ortar G, McNicol A. The effects of an inhibitor of diglyceride lipase on collagen-induced platelet activation. J Pharmacol Exp Ther. 2013 Dec;347(3):582-8. doi: 10.1124/jpet.113.205591. Epub 2013 Sep 16. PubMed PMID: 24042163.
4: Hashimotodani Y, Ohno-Shosaku T, Tanimura A, Kita Y, Sano Y, Shimizu T, Di Marzo V, Kano M. Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. J Physiol. 2013 Oct 1;591(19):4765-76. doi: 10.1113/jphysiol.2013.254474. Epub 2013 Jul 15. PubMed PMID: 23858009; PubMed Central PMCID: PMC3800453.
5: Min R, Testa-Silva G, Heistek TS, Canto CB, Lodder JC, Bisogno T, Di Marzo V, Brussaard AB, Burnashev N, Mansvelder HD. Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus. J Neurosci. 2010 Feb 17;30(7):2710-5. doi: 10.1523/JNEUROSCI.BC-3622-09.2010. PubMed PMID: 20164355.
