WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564485
Description: Ornithine-α-ketoglutarate is a modulator of the respiratory burst via nitric oxide and polyamine generation, thereby improving immune status during stress.
MedKoo Cat#: 564485
Chemical Formula: C10H18N2O7
Exact Mass: 278.1114
Molecular Weight: 278.26
Elemental Analysis: C, 43.16; H, 6.52; N, 10.07; O, 40.25
Synonym: OKG; L-Ornithine-α-ketoglutarate; L Ornithine α ketoglutarate; Ornithine-α-ketoglutarate; Ornithine α-ketoglutarate; Ornithine α ketoglutarate; Ornithine alpha ketoglutarate
IUPAC/Chemical Name: (S)-2,5-Diaminopentanoic acid compound with 2-oxopentanedioic acid
InChi Key: SLPUVFBNQHVEEU-WCCKRBBISA-N
InChi Code: InChI=1S/C5H12N2O2.C5H6O5/c6-3-1-2-4(7)5(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,6-7H2,(H,8,9);1-2H2,(H,7,8)(H,9,10)/t4-;/m0./s1
SMILES Code: O=C(O)[C@@H](N)CCCN.O=C(O)C(CCC(O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 278.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Roch-Arveiller M, Tissot M, Coudray-Lucas C, Fontagné J, Le Boucher J, Giroud JP, Cynober L. Immunomodulatory effects of ornithine alpha-ketoglutarate in rats with burn injuries. Arch Surg. 1996 Jul;131(7):718-23. PubMed PMID: 8678770.
2: Le Bricon T, Cynober L, Field CJ, Baracos VE. Supplemental nutrition with ornithine alpha-ketoglutarate in rats with cancer-associated cachexia: surgical treatment of the tumor improves efficacy of nutritional support. J Nutr. 1995 Dec;125(12):2999-3010. PubMed PMID: 7500178.
3: Cynober L. Ornithine alpha-ketoglutarate in nutritional support. Nutrition. 1991 Sep-Oct;7(5):313-22. Review. PubMed PMID: 1804465.
4: Guimarães Filho A, Cunha RM, Vasconcelos PR, Guimarães SB. Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydrogenases expression in hepatectomized rats. Acta Cir Bras. 2014 Jun;29(6):365-70. PubMed PMID: 24919044.