WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584675
CAS#: 13085-08-0
Description: Mazipredone is a water-soluble, long-acting prednisolone derivative used topically for skin conditions & parenterally as a glucocorticoid.
MedKoo Cat#: 584675
Name: Mazipredone
CAS#: 13085-08-0
Chemical Formula: C26H38N2O4
Exact Mass: 442.2832
Molecular Weight: 442.6
Elemental Analysis: C, 70.56; H, 8.65; N, 6.33; O, 14.46
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Mazipredone; Mazipredona; Mazipredonum
IUPAC/Chemical Name: 11beta,17-Dihydroxy-21-(4-methyl-1-piperazinyl)pregna-1,4-diene-3,20-dione
InChi Key: CZBOZZDZNVIXFC-VRRJBYJJSA-N
InChi Code: InChI=1S/C26H38N2O4/c1-24-8-6-18(29)14-17(24)4-5-19-20-7-9-26(32,25(20,2)15-21(30)23(19)24)22(31)16-28-12-10-27(3)11-13-28/h6,8,14,19-21,23,30,32H,4-5,7,9-13,15-16H2,1-3H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1
SMILES Code: C[C@@]12[C@](C(CN3CCN(C)CC3)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 442.6 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Gazdag M, Babják M, Brlik J, Mahó S, Tuba Z, Görög S. Estimation of impurity profiles of drugs and related materials Part 18. Impurities and degradation products of mazipredone. J Pharm Biomed Anal. 1998 Sep 1;17(6-7):1029-36. PubMed PMID: 9884192.
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4: Görög S. The paradigm shifting role of chromatographic methods in pharmaceutical analysis. J Pharm Biomed Anal. 2012 Oct;69:2-8. doi: 10.1016/j.jpba.2012.01.031. Epub 2012 Jan 30. Review. PubMed PMID: 22341481.
5: Görög S, Babják M, Balogh G, Brlik J, Csehi A, Dravecz F, Gasdag M, Horváth P, Laukó A, Varga K. Drug impurity profiling strategies. Talanta. 1997 Sep;44(9):1517-26. PubMed PMID: 18966892.
6: Görög S, Babják M, Balogh G, Brlik J, Dravecz F, Gazdag M, Horváth P, Laukó A, Varga K. Estimation of impurity profiles of drugs and related materials: part 19: theme with variations. Identification of impurities in 3-oxosteroids. J Pharm Biomed Anal. 1998 Dec;18(4-5):511-25. PubMed PMID: 9919951.
7: LUKATS B, TAKACSINAGY G. [COLOR REACTION OF O-DINITROBENZENE AND ITS USE IN MEASURING SOME STEROID COMPOUNDS AND IN THE STUDY OF THE STABILITY OF DEPERSOLONE]. Acta Pharm Hung. 1965 May;35:116-22. Hungarian. PubMed PMID: 14313169.
