666-15
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564474

CAS#: 1433286-70-4

Description: 666-15 is a potent and cell-permeable inhibitor of cAMP-response element binding protein (CREB). 666-15 has efficacious anti-cancer activity both in vitro and in vivo.


Chemical Structure

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666-15
CAS# 1433286-70-4

Theoretical Analysis

MedKoo Cat#: 564474
Name: 666-15
CAS#: 1433286-70-4
Chemical Formula: C33H31Cl2N3O5
Exact Mass:
Molecular Weight: 620.53
Elemental Analysis: C, 63.88; H, 5.04; Cl, 11.43; N, 6.77; O, 12.89

Price and Availability

Size Price Availability Quantity
10.0mg USD 415.0 2 Weeks
50.0mg USD 1185.0 2 Weeks
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Synonym: 66615; 666 15; 666-15

IUPAC/Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

InChi Key: LELLCPHHYHLWBH-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H30ClN3O5.ClH/c34-25-10-11-28(29(38)20-25)37-33(40)27-17-22-7-2-4-9-24(22)19-31(27)42-15-13-36-32(39)26-16-21-6-1-3-8-23(21)18-30(26)41-14-5-12-35;/h1-4,6-11,16-20,38H,5,12-15,35H2,(H,36,39)(H,37,40);1H

SMILES Code: O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NCCOC3=C(C(NC4=CC=C(Cl)C=C4O)=O)C=C5C=CC=CC5=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 620.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Narasimhan G, Carrillo ED, Hernández A, García MC, Sánchez JA. Protective Action of Diazoxide on Isoproterenol-Induced Hypertrophy Is Mediated by Reduction in MicroRNA-132 Expression. J Cardiovasc Pharmacol. 2018 Nov;72(5):222-230. doi: 10.1097/FJC.0000000000000619. PubMed PMID: 30403388.

2: Xie F, Li BX, Xiao X. Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2017 Feb 15;27(4):994-998. doi: 10.1016/j.bmcl.2016.12.078. Epub 2016 Dec 31. PubMed PMID: 28073675; PubMed Central PMCID: PMC5296214.

3: Li BX, Gardner R, Xue C, Qian DZ, Xie F, Thomas G, Kazmierczak SC, Habecker BA, Xiao X. Systemic Inhibition of CREB is Well-tolerated in vivo. Sci Rep. 2016 Oct 3;6:34513. doi: 10.1038/srep34513. PubMed PMID: 27694829; PubMed Central PMCID: PMC5046085.

4: Xie F, Li BX, Kassenbrock A, Xue C, Wang X, Qian DZ, Sears RC, Xiao X. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87. doi: 10.1021/acs.jmedchem.5b00468. Epub 2015 Jun 5. PubMed PMID: 26023867; PubMed Central PMCID: PMC4493896.

666-15

10.0mg / USD 415.0