AKOS024836912

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564453

CAS#: 1705763-81-0

Description: AKOS024836912 is an inhibitor of EGF-EGFR interactions.


Chemical Structure

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AKOS024836912
CAS# 1705763-81-0

Theoretical Analysis

MedKoo Cat#: 564453
Name: AKOS024836912
CAS#: 1705763-81-0
Chemical Formula: C18H23N5O2
Exact Mass: 341.19
Molecular Weight: 341.420
Elemental Analysis: C, 63.32; H, 6.79; N, 20.51; O, 9.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AKOS-024836912; AKOS 024836912; AKOS024836912

IUPAC/Chemical Name: 1-(2-Methoxy-5-methylphenyl)-3-(6-(piperidin-1-yl)pyrimidin-4-yl)urea

InChi Key: VBVZTPNOOLFLHE-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H23N5O2/c1-13-6-7-15(25-2)14(10-13)21-18(24)22-16-11-17(20-12-19-16)23-8-4-3-5-9-23/h6-7,10-12H,3-5,8-9H2,1-2H3,(H2,19,20,21,22,24)

SMILES Code: O=C(NC1=NC=NC(N2CCCCC2)=C1)NC3=CC(C)=CC=C3OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 341.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gudala S, Khan U, Kanungo N, Bandaru S, Hussain T, Parihar M, Nayarisseri A, Mundluru HP. Identification and Pharmacological Analysis of High Efficacy Small Molecule Inhibitors of EGF-EGFR Interactions in Clinical Treatment of Non-Small Cell Lung Carcinoma: a Computational Approach. Asian Pac J Cancer Prev. 2015;16(18):8191-6. PubMed PMID: 26745059.