ULK-101
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MedKoo CAT#: 407951

CAS#: 2443816-45-1

Description: ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM. ULK-101 suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. ULK-101 represents a powerful molecular tool to study the role of autophagy in cancer cells and to evaluate the therapeutic potential of autophagy inhibition.


Price and Availability

Size Price Shipping out time Quantity
1g USD 3850 2-3 months
2g USD 6950 2-3 months
5g USD 12950 2-3 months
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

ULK-101 is out of stock. We can make a new batch for customer. Lead time is 2~3 months.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407951
Name: ULK-101
CAS#: 2443816-45-1
Chemical Formula: C22H16F4N4OS
Exact Mass: 460.0981
Molecular Weight: 460.4506
Elemental Analysis: C, 57.39; H, 3.50; F, 16.50; N, 12.17; O, 3.47; S, 6.96


Synonym: ULK-101; ULK 101; ULK101;

IUPAC/Chemical Name: (S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

InChi Key: PFZRXJIYAFANHP-IBGZPJMESA-N

InChi Code: InChI=1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1

SMILES Code: O=C(C1=CC(C2=C3N=CC(C4=CC=C(F)C=C4)=CN3N=C2)=CS1)N[C@@H](C5CC5)C(F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD,
Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses
Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct
26;8:74-84. doi: 10.1016/j.isci.2018.09.012. Epub 2018 Sep 19. PubMed PMID:
30292171; PubMed Central PMCID: PMC6172447.