WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564429
CAS#: 432016-77-8 (free base)
Description: W2476 is a modulator of the thioredoxin-interacting protein signaling pathway, which ameliorates ß-cell dysfunction and exerts therapeutic effects in mouse models of diabetes.
MedKoo Cat#: 564429
Name: W2476
CAS#: 432016-77-8 (free base)
Chemical Formula: C15H15N5O2
Exact Mass: 297.1226
Molecular Weight: 297.32
Elemental Analysis: C, 60.60; H, 5.09; N, 23.56; O, 10.76
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 432016-77-8 (free base) 1217067-40-7 (HCl)
Synonym: W-2476; W 2476; W2476
IUPAC/Chemical Name: 1-(4-(2-(6-amino-9H-purin-9-yl)ethoxy)phenyl)ethan-1-one
InChi Key: ONZGILNKQYWMNI-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H15N5O2/c1-10(21)11-2-4-12(5-3-11)22-7-6-20-9-19-13-14(16)17-8-18-15(13)20/h2-5,8-9H,6-7H2,1H3,(H2,16,17,18)
SMILES Code: CC(C1=CC=C(OCCN2C=NC3=C(N)N=CN=C23)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 297.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Li T, Lin GY, Zhong L, Zhou Y, Wang J, Zhu Y, Feng Y, Cai XQ, Liu Q, Nosjean O, Boutin JA, Renard P, Yang DH, Wang MW. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta Pharmacol Sin. 2017 Jul;38(7):1024-1037. doi: 10.1038/aps.2017.15. Epub 2017 May 15. PubMed PMID: 28502980; PubMed Central PMCID: PMC5519249.
2: Zhong L, Liu Q, Ting YS, Thien VY, Binti Kalong NS, Yang D, Wang MW. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chem Biol Drug Des. 2018 Jul 25. doi: 10.1111/cbdd.13371. [Epub ahead of print] PubMed PMID: 30043441.
