M 8506

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584658

CAS#: 93245-29-5

Description: M 8506 can be used in the treatment of simian malaria and is is less toxic than primaquine in mice.

Chemical Structure

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M 8506
CAS# 93245-29-5
Instruction

Theoretical Analysis

MedKoo Cat#: 584658
Name: M 8506
CAS#: 93245-29-5
Chemical Formula: C19H22F3N3O6
Exact Mass: 445.15
Molecular Weight: 445.395
Elemental Analysis: C, 51.24; H, 4.98; F, 12.80; N, 9.43; O, 21.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: M 8506; M-8506; Trifluoroacetylprimaquine

IUPAC/Chemical Name: Ethanone, 1-(8-((4-amino-1-methylbutyl)amino)-6-methoxy-5-quinolinyl)-2,2,2-trifluoro-, ethanedioate (1:1)

InChi Key: WEFNQSNREJZFQJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20F3N3O2.C2H2O4/c1-10(5-3-7-21)23-12-9-13(25-2)14(16(24)17(18,19)20)11-6-4-8-22-15(11)12;3-1(4)2(5)6/h4,6,8-10,23H,3,5,7,21H2,1-2H3;(H,3,4)(H,5,6)

SMILES Code: FC(F)(F)C(C1=C2C=CC=NC2=C(NC(C)CCCN)C=C1OC)=O.O=C(O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ye XY, Shao BR. [Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine]. Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):359-62. Chinese. PubMed PMID: 2104491.

2: Ni YC, Xu YQ. [In vitro assay for detecting hemolytic toxicity of antimalarials incorporated with microsomal metabolic system]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1990;8(4):256-9. Chinese. PubMed PMID: 2099253.

3: Zheng XY, Chen C, Fang W. [Studies on the tissue schizonticide of malaria parasite: synthesis of 5-trieluoroacetyl-primaquine and its derivatives]. Yao Xue Xue Bao. 1992;27(6):423-7. Chinese. PubMed PMID: 1442069.

4: Shi X, Zhan C, Ha S, Yiao J. [Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(3):218-20. Chinese. PubMed PMID: 7867160.

5: Ye X, Shao B, Chu Y. [Effect of trifluoroacetoprimaquine on erythrocytic schizonts of rodent malaria]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(3):223-4. Chinese. PubMed PMID: 7867162.

6: Shao BR, Ye XY. Tissue schizontocidal effect of trifluoroacetyl primaquine in Plasmodium yoelii infected mice and Plasmodium cynomolgi infected monkeys. Southeast Asian J Trop Med Public Health. 1991 Mar;22(1):81-3. PubMed PMID: 1948265.