WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581571
Description: 7α-Thio Spironolactone is a Spironolactone (sc-204294) metabolite.
MedKoo Cat#: 581571
Chemical Formula: C22H30O3S
Exact Mass: 374.1916
Molecular Weight: 374.539
Elemental Analysis: C, 70.55; H, 8.07; O, 12.81; S, 8.56
Synonym: 7alpha-Thiospironolactone; Deacetylspironolactone;
IUPAC/Chemical Name: (7R,8R,9S,10S,13R,14S,17R)-7-mercapto-10,13-dimethyl-1,3',4',6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione
InChi Key: NZCDWYJROUPYPT-BIPXHUIRSA-N
InChi Code: InChI=1S/C22H30O3S/c1-20-7-3-14(23)11-13(20)12-17(26)19-15(20)4-8-21(2)16(19)5-9-22(21)10-6-18(24)25-22/h11,15-17,19,26H,3-10,12H2,1-2H3/t15-,16-,17+,19+,20+,21+,22+/m0/s1
SMILES Code: C1CC(O[C@@]21CC[C@H]1[C@H]3[C@H](CC[C@@]21C)[C@@]1(CCC(C=C1C[C@H]3S)=O)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 374.539 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: B S, G S, V KR, S G. Microbial synthesis of mammalian metabolites of spironolactone by thermophilic fungus Thermomyces lanuginosus. Steroids. 2018 Aug;136:1-7. doi: 10.1016/j.steroids.2018.05.011. Epub 2018 May 25. PubMed PMID: 29803817.