T-2 triol
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581564

CAS#: 34114-98-2

Description: T-2 Mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and animals.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 770 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-02. Prices are subject to change without notice.

T-2 triol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 581564
Name: T-2 triol
CAS#: 34114-98-2
Chemical Formula: C20H30O7
Exact Mass: 382.1992
Molecular Weight: 382.45
Elemental Analysis: C, 62.81; H, 7.91; O, 29.28


Synonym: T-2 triol; Toxin T-2 triol; Deacetyl-HT-2 toxin

IUPAC/Chemical Name: 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate

InChi Key: DDAUKBBLCGQHIP-CAVDVMKYSA-N

InChi Code: InChI=1S/C20H30O7/c1-10(2)5-14(22)26-12-7-19(8-21)13(6-11(12)3)27-17-15(23)16(24)18(19,4)20(17)9-25-20/h6,10,12-13,15-17,21,23-24H,5,7-9H2,1-4H3/t12-,13+,15+,16+,17+,18+,19+,20-/m0/s1

SMILES Code: C[C@@]12[C@H](O)[C@@H](O)[C@H]([C@@]23CO3)O[C@]4([H])C=C(C)[C@@H](OC(CC(C)C)=O)C[C@]14CO


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Michlmayr H, Varga E, Malachová A, Fruhmann P, Piątkowska M, Hametner C, Šofrová J, Jaunecker G, Häubl G, Lemmens M, Berthiller F, Adam G. UDP-Glucosyltransferases from Rice, Brachypodium, and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-d-glucosides. Toxins (Basel). 2018 Mar 6;10(3). pii: E111. doi: 10.3390/toxins10030111. PubMed PMID: 29509722; PubMed Central PMCID: PMC5869399.

2: Gao X, Mu P, Wen J, Sun Y, Chen Q, Deng Y. Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9. Food Chem Toxicol. 2018 Feb;112:310-319. doi: 10.1016/j.fct.2017.12.066. Epub 2017 Dec 30. PubMed PMID: 29294345.

3: Broekaert N, Devreese M, De Boevre M, De Saeger S, Croubels S. T-2 Toxin-3α-glucoside in Broiler Chickens: Toxicokinetics, Absolute Oral Bioavailability, and in Vivo Hydrolysis. J Agric Food Chem. 2017 Jun 14;65(23):4797-4803. doi: 10.1021/acs.jafc.7b00698. Epub 2017 May 31. PubMed PMID: 28520442.

4: Bernhardt K, Valenta H, Kersten S, Humpf HU, Dänicke S. Determination of T-2 toxin, HT-2 toxin, and three other type A trichothecenes in layer feed by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)--comparison of two sample preparation methods. Mycotoxin Res. 2016 May;32(2):89-97. doi: 10.1007/s12550-016-0244-z. Epub 2016 Mar 4. PubMed PMID: 26940912.

5: Góral T, Stuper-Szablewska K, Buśko M, Boczkowska M, Walentyn-Góral D, Wiśniewska H, Perkowski J. Relationships between Genetic Diversity and Fusarium Toxin Profiles of Winter Wheat Cultivars. Plant Pathol J. 2015 Sep;31(3):226-44. doi: 10.5423/PPJ.OA.03.2015.0038. Epub 2015 Sep 30. PubMed PMID: 26361471; PubMed Central PMCID: PMC4564148.

6: Yang S, Wang Y, Beier RC, Zhang H, De Ruyck K, Sun F, Cao X, Shen J, Zhang S, Wang Z. Simultaneous Determination of Type A and B Trichothecenes and Their Main Metabolites in Food Animal Tissues by Ultraperformance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry. J Agric Food Chem. 2015 Sep 30;63(38):8592-600. doi: 10.1021/acs.jafc.5b03281. Epub 2015 Sep 16. PubMed PMID: 26321427.

7: Sun YX, Yao X, Shi SN, Zhang GJ, Xu LX, Liu YJ, Fang BH. Toxicokinetics of T-2 toxin and its major metabolites in broiler chickens after intravenous and oral administration. J Vet Pharmacol Ther. 2015 Feb;38(1):80-5. doi: 10.1111/jvp.12142. Epub 2014 Jul 31. PubMed PMID: 25079675.

8: Rubert J, León N, Sáez C, Martins CP, Godula M, Yusà V, Mañes J, Soriano JM, Soler C. Evaluation of mycotoxins and their metabolites in human breast milk using liquid chromatography coupled to high resolution mass spectrometry. Anal Chim Acta. 2014 Apr 11;820:39-46. doi: 10.1016/j.aca.2014.02.009. Epub 2014 Feb 12. PubMed PMID: 24745736.

9: Sun Y, Zhang G, Zhao H, Zheng J, Hu F, Fang B. Liquid chromatography-tandem mass spectrometry method for toxicokinetics, tissue distribution, and excretion studies of T-2 toxin and its major metabolites in pigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:75-82. doi: 10.1016/j.jchromb.2014.03.010. Epub 2014 Mar 19. PubMed PMID: 24705534.

10: Chen D, Cao X, Tao Y, Wu Q, Pan Y, Peng D, Liu Z, Huang L, Wang Y, Wang X, Yuan Z. Development of a liquid chromatography-tandem mass spectrometry with ultrasound-assisted extraction and auto solid-phase clean-up method for the determination of Fusarium toxins in animal derived foods. J Chromatogr A. 2013 Oct 11;1311:21-9. doi: 10.1016/j.chroma.2013.08.062. Epub 2013 Aug 21. PubMed PMID: 24011505.

11: Schollenberger M, Müller HM, Ernst K, Sondermann S, Liebscher M, Schlecker C, Wischer G, Drochner W, Hartung K, Piepho HP. Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany. Toxins (Basel). 2012 Oct;4(10):778-87. doi: 10.3390/toxins4100778. Epub 2012 Sep 28. PubMed PMID: 23162697; PubMed Central PMCID: PMC3496988.

12: Schollenberger M, Müller HM, Liebscher M, Schlecker C, Berger M, Hermann W. Accumulation kinetics of three scirpentriol-based toxins in oats inoculated in Vitro with isolates of Fusarium sporotrichioides and Fusarium poae. Toxins (Basel). 2011 May;3(5):442-52. doi: 10.3390/toxins3050442. Epub 2011 May 9. PubMed PMID: 22069718; PubMed Central PMCID: PMC3202831.

13: Tan DC, Flematti GR, Ghisalberti EL, Sivasithamparam K, Chakraborty S, Obanor F, Barbetti MJ. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. doi: 10.1007/s12550-010-0085-0. Epub 2011 Jan 12. PubMed PMID: 23605703.

14: Zaĭchenko AM, Nagornaia SS, Andrienko EV, Tsyganenko ES. [Study of specificity of fungistatic effect of trichothecene mycotoxins]. Mikrobiol Z. 2009 Mar-Apr;71(2):57-62. Russian. PubMed PMID: 19938595.

15: Edwards SG. Fusarium mycotoxin content of UK organic and conventional oats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jul;26(7):1063-9. doi: 10.1080/02652030902788953. PubMed PMID: 19680981.

16: Edwards SG. Fusarium mycotoxin content of UK organic and conventional wheat. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Apr;26(4):496-506. doi: 10.1080/02652030802530679. PubMed PMID: 19680924.

17: Wu Q, Dohnal V, Huang L, Kuca K, Yuan Z. Metabolic pathways of trichothecenes. Drug Metab Rev. 2010 May;42(2):250-67. doi: 10.1080/03602530903125807. Review. PubMed PMID: 19678805.

18: Königs M, Mulac D, Schwerdt G, Gekle M, Humpf HU. Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Toxicology. 2009 Apr 28;258(2-3):106-15. doi: 10.1016/j.tox.2009.01.012. Epub 2009 Jan 20. PubMed PMID: 19428930.

19: Beyer M, Ferse I, Humpf HU. Large-scale production of selected type A trichothecenes: the use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin. Mycotoxin Res. 2009 Mar;25(1):41-52. doi: 10.1007/s12550-009-0006-2. Epub 2009 Mar 3. PubMed PMID: 23604935.

20: Jeleń HH, Wasowicz E. Determination of trichothecenes in wheat grain without sample cleanup using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. J Chromatogr A. 2008 Dec 26;1215(1-2):203-7. doi: 10.1016/j.chroma.2008.11.007. Epub 2008 Nov 7. PubMed PMID: 19036380.