Amisometradine
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MedKoo CAT#: 573139

CAS#: 550-28-7

Description: Amisometradine is a diuretic which may be used in the treatment of congestive heart failure.

Chemical Structure

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Amisometradine
CAS# 550-28-7
Instruction

Theoretical Analysis

MedKoo Cat#: 573139
Name: Amisometradine
CAS#: 550-28-7
Chemical Formula: C9H13N3O2
Exact Mass: 195.10
Molecular Weight: 195.220
Elemental Analysis: C, 55.37; H, 6.71; N, 21.52; O, 16.39

Price and Availability

Size Price Availability Quantity
5mg USD 230
25mg USD 440
50mg USD 725
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Synonym: Amisometradine, Aminoisometradin, Aminoisometradine, Rolicton

IUPAC/Chemical Name: 6-Amino-3-methyl-1-(2-methylallyl)-2,4(1H,3H)-pyrimidinedione

InChi Key: FXNYSZHYMGWWEZ-UHFFFAOYSA-N

InChi Code: 1S/C9H13N3O2/c1-6(2)5-12-7(10)4-8(13)11(3)9(12)14/h4H,1,5,10H2,2-3H3

SMILES Code: n1(c(n(c(=O)cc1N)C)=O)CC(C)=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 195.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: VAN ARMAN CG, DETTELBACH HR, KAGAWA CM. A uracil diuretic: amisometradine (rolicton). Arch Int Pharmacodyn Ther. 1960 Jul 1;126:400-11. PubMed PMID: 13840955.

2: PLATTS MM. Amisometradine (rolicton) in the treatment of congestive heart failure. Br Heart J. 1959 Apr;21(2):249-54. PubMed PMID: 13651512; PubMed Central PMCID: PMC1017575.

3: BRUERA EF, BLANCO F, FERRARIO R, SCHILIAGGI E, GASPARY FV. [Comparative study of the diuretic effect of a mercurial, chlorothiazide & amisometradine]. Sem Med. 1959 Mar 26;114(13):404-7 passim. Spanish. PubMed PMID: 13659079.

4: SETTEL E. Observations on the prolonged administration of amisometradine. Am Pract Dig Treat. 1959 Mar;10(3):479-83. PubMed PMID: 13627415.

5: JOSE AD, WOOD P. Amisometradine, a new oral diuretic. Br Med J. 1958 Jan 4;1(5061):9-12. PubMed PMID: 13489295; PubMed Central PMCID: PMC2026628.

6: BELLE MS. Clinical experience with amisometradine (rolicton) on ambulatory patients. Am Heart J. 1958 Jan;55(1):114-9. PubMed PMID: 13520557.