WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584649
CAS#: 2141-09-5
Description: Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities.
MedKoo Cat#: 584649
Name: Magnoflorine
CAS#: 2141-09-5
Chemical Formula: C20H24NO4+
Exact Mass: 342.17
Molecular Weight: 342.4145
Elemental Analysis: C, 70.15; H, 7.07; N, 4.09; O, 18.69
Synonym: Magnoflorine; (+)-Magnoflorine; α-Magnoflorine
IUPAC/Chemical Name: 5,6,6aS,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium
InChi Key: YLRXAIKMLINXQY-ZDUSSCGKSA-O
InChi Code: InChI=1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
SMILES Code: C[N+]1(C)CCC2=CC(OC)=C(O)C3=C2[C@]1([H])CC4=CC=C(OC)C(O)=C34
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 342.4145 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Sakumoto, H., Yokota, Y., Ishibashi, G., et al. Sinomenine and magnoflorine, major constituents of Sinomeni caulis et rhizoma, show potent protective effects against membrane damage induced by lysophosphatidylcholine in rat erythrocytes. J. Nat. Med. 69(3), 441-448 (2015).
2. de la Peña, J.B.I., Lee, H.L., Yoon, S.Y., et al. The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice. J. Nat. Med. 67(4), 814-821 (2013).
3. Sun, D., Zhou, M., Ying, X., et al. Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. BMC Complement. Altern. Med. 14, 356 (2014).
4. Kukula-Koch, W., Kruk-Słomka, M., Stępnik, K., et al. The evaluation of pro-cognitive and antiamnestic properties of berberine and magnoflorine isolated from barberry species by centrifugal partition chromatography (CPC), in relation to QSAR modelling. Int. J. Mol. Sci. 18(12), E2511 (2017).
