WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564330
Description: MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation.
MedKoo Cat#: 564330
Chemical Formula: C18H21IN4O2S
Exact Mass: 484.043
Molecular Weight: 484.36
Elemental Analysis: C, 44.64; H, 4.37; I, 26.20; N, 11.57; O, 6.61; S, 6.62
This product is not in stock, which may be available by custom synthesis.
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Synonym: MB-725; MB 725; MB725
IUPAC/Chemical Name: 2-(Diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide
InChi Key: GBNAUQMZRRFQTA-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H21IN4O2S/c1-4-20-17(25)11-13-16(26-18(21-13)22(5-2)6-3)14(12(19)15(11)24)23-9-7-8-10-23/h7-10,24H,4-6H2,1-3H3,(H,20,25)
SMILES Code: O=C(C1=C2N=C(N(CC)CC)SC2=C(N3C=CC=C3)C(I)=C1O)NCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 484.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Baud MGJ, Bauer MR, Verduci L, Dingler FA, Patel KJ, Horil Roy D, Joerger AC, Fersht AR. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114. doi: 10.1016/j.ejmech.2018.04.035. Epub 2018 Apr 21. PubMed PMID: 29702446; PubMed Central PMCID: PMC5986712.