SSE15206
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MedKoo CAT#: 407940

CAS#: 1370046-40-4

Description: SSE15206 is a microtubule depolymerizing agent that overcomes multidrug resistance. SSE15206 has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin as shown by docking and competition studies..


Chemical Structure

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SSE15206
CAS# 1370046-40-4

Theoretical Analysis

MedKoo Cat#: 407940
Name: SSE15206
CAS#: 1370046-40-4
Chemical Formula: C19H21N3O3S
Exact Mass: 371.13
Molecular Weight: 371.455
Elemental Analysis: C, 61.44; H, 5.70; N, 11.31; O, 12.92; S, 8.63

Price and Availability

Size Price Availability Quantity
25mg USD 120 Ready to ship
50mg USD 190 Ready to ship
100mg USD 350 Ready to ship
200mg USD 630 Ready to ship
500mg USD 1350 Ready to ship
1g USD 2250 Ready to ship
2g USD 4250 2 Weeks
5g USD 6950 2 Weeks
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Synonym: SSE15206; SSE-15206; SSE 15206;

IUPAC/Chemical Name: 4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide

InChi Key: GONIBFCARADPAC-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N3O3S/c1-23-16-9-13(10-17(24-2)18(16)25-3)15-11-14(21-22(15)19(20)26)12-7-5-4-6-8-12/h4-10,15H,11H2,1-3H3,(H2,20,26)

SMILES Code: S=C(N1N=C(C2=CC=CC=C2)CC1C3=CC(OC)=C(OC)C(OC)=C3)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells).
In vitro activity: This study describes the synthesis and characterization of SSE15206. It can overcome drug resistance, including multidrug resistance, to MTAs. SSE15206 inhibits microtubule polymerization to induce apoptosis in various cancer cells. Importantly, it inhibits proliferation of paclitaxel-resistant cells, including MDR-1 expressing multidrug resistant cells, indicating that it is not affected by P-glycoprotein (Pgp). Reference: Sci Rep. 2018; 8: 3305. https://pubmed.ncbi.nlm.nih.gov/29459693/
In vivo activity: To be determined

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 112.0 301.52

Preparing Stock Solutions

The following data is based on the product molecular weight 371.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Ma L, Lei J, Chen H, Huang R, Su T, Feng J, Sun Q. Structural insight into SSE15206 in complex with tubulin provides a rational design for pyrazolinethioamides as tubulin polymerization inhibitors. Future Med Chem. 2022 Jun;14(11):785-794. doi: 10.4155/fmc-2021-0124. Epub 2022 May 4. PMID: 35506429. 2. Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X, Jawaid A, Saleem RSZ, Faisal A. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305. doi: 10.1038/s41598-018-21642-0. Erratum in: Sci Rep. 2018 Apr 18;8(1):6427. PMID: 29459693; PMCID: PMC5818492.
In vitro protocol: 1. Ma L, Lei J, Chen H, Huang R, Su T, Feng J, Sun Q. Structural insight into SSE15206 in complex with tubulin provides a rational design for pyrazolinethioamides as tubulin polymerization inhibitors. Future Med Chem. 2022 Jun;14(11):785-794. doi: 10.4155/fmc-2021-0124. Epub 2022 May 4. PMID: 35506429. 2. Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X, Jawaid A, Saleem RSZ, Faisal A. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305. doi: 10.1038/s41598-018-21642-0. Erratum in: Sci Rep. 2018 Apr 18;8(1):6427. PMID: 29459693; PMCID: PMC5818492.
In vivo protocol: To be determined

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1: Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X,
Jawaid A, Saleem RSZ, Faisal A. Author Correction: Identification and
characterization of SSE15206, a microtubule depolymerizing agent that overcomes
multidrug resistance. Sci Rep. 2018 Apr 18;8(1):6427. doi:
10.1038/s41598-018-24114-7. PubMed PMID: 29666376; PubMed Central PMCID:
PMC5904161.


2: Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X,
Jawaid A, Saleem RSZ, Faisal A. Identification and characterization of SSE15206,
a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep.
2018 Feb 19;8(1):3305. doi: 10.1038/s41598-018-21642-0. Erratum in: Sci Rep. 2018
Apr 18;8(1):6427. PubMed PMID: 29459693; PubMed Central PMCID: PMC5818492.