ZJ01

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564317

CAS#: NONE

Description: ZJ01 is a Keap1-Nrf2 protein-protein interaction (PPI) inhibitor.


Chemical Structure

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ZJ01
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 564317
Name: ZJ01
CAS#: NONE
Chemical Formula: C24H23N3O3S
Exact Mass: 433.15
Molecular Weight: 433.530
Elemental Analysis: C, 66.49; H, 5.35; N, 9.69; O, 11.07; S, 7.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ZJ-01; ZJ 01; ZJ01

IUPAC/Chemical Name: Allyl (Z)-(3-(benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-ylidene)carbamate

InChi Key: HBWNDXAVUPAAIJ-ROMGYVFFSA-N

InChi Code: InChI=1S/C24H23N3O3S/c1-4-13-29-24(28)26-22-18(23-25-19-9-7-8-10-21(19)31-23)14-16-11-12-17(15-20(16)30-22)27(5-2)6-3/h4,7-12,14-15H,1,5-6,13H2,2-3H3/b26-22-

SMILES Code: O=C(OCC=C)/N=C1C(C2=NC3=CC=CC=C3S2)=CC4=C(O/1)C=C(N(CC)CC)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 433.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jiang CS, Zhuang CL, Zhu K, Zhang J, Muehlmann LA, Figueiró Longo JP, Azevedo RB, Zhang W, Meng N, Zhang H. Identification of a novel small-molecule Keap1-Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy. J Enzyme Inhib Med Chem. 2018 Dec;33(1):833-841. doi: 10.1080/14756366.2018.1461856. PubMed PMID: 29693453; PubMed Central PMCID: PMC6009974.