We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564316


Description: NUC041 is a prodrug of NUC013, which is a novel DNA methytransferase inhibitor.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NUC041 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 564316
Name: NUC041
Chemical Formula: C14H26F2N4O4Si2
Exact Mass: 408.1461
Molecular Weight: 408.55
Elemental Analysis: C, 41.16; H, 6.41; F, 9.30; N, 13.71; O, 15.66; Si, 13.75

Synonym: NUC-041; NUC 041; NUC041

IUPAC/Chemical Name: 3',5'-Di-trimethylsilyl-2',2'-difluoro-5-azadeoxycytidine


InChi Code: InChI=1S/C14H26F2N4O4Si2/c1-25(2,3)9(21)8-14(23,26(4,5)6)13(15,16)10(24-8)20-7-18-11(17)19-12(20)22/h7-10,21,23H,1-6H3,(H2,17,19,22)/t8-,9?,10-,14+/m1/s1

SMILES Code: OC([Si](C)(C)C)[C@@H]1[C@@](C(F)(F)[C@H](N2C(N=C(N=C2)N)=O)O1)([Si](C)(C)C)O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Daifuku R, Grimes S, Stackhouse M. NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2',2'-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer. Pharmaceuticals (Basel). 2018 Apr 23;11(2). pii: E36. doi: 10.3390/ph11020036. PubMed PMID: 29690576; PubMed Central PMCID: PMC6027359.