NUC013

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MedKoo CAT#: 564315

CAS#: NONE

Description: NUC013 is a DNA methytransferase inhibitor which has been shown to be significantly safer and more effective than decitabine in xenograft models of human leukemia and colon cancer. NUC013 was shown to significantly inhibit tumor growth and improve survival in a NCI-H460 xenograft of non-small cell lung cancer.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-08. Prices are subject to change without notice.

NUC013 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564315
Name: NUC013
CAS#: NONE
Chemical Formula: C8H10F2N4O4
Exact Mass: 264.067
Molecular Weight: 264.19
Elemental Analysis: C, 36.37; H, 3.82; F, 14.38; N, 21.21; O, 24.22


Synonym: NUC-013; NUC 013; NUC013

IUPAC/Chemical Name: 5-Aza-2',2'-Difluorodeoxycytidine; 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one

InChi Key: GQGVBSHMRYHBTF-UOWFLXDJSA-N

InChi Code: InChI=1S/C8H10F2N4O4/c9-8(10)4(16)3(1-15)18-5(8)14-2-12-6(11)13-7(14)17/h2-5,15-16H,1H2,(H2,11,13,17)/t3-,4-,5-/m1/s1

SMILES Code: OC[C@@H]1[C@H](C(F)(F)[C@H](N2C(N=C(N=C2)N)=O)O1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Daifuku R, Grimes S, Stackhouse M. NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2',2'-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer. Pharmaceuticals (Basel). 2018 Apr 23;11(2). pii: E36. doi: 10.3390/ph11020036. PubMed PMID: 29690576; PubMed Central PMCID: PMC6027359.

2: Daifuku R, Hu Z, Saunthararajah Y. 5-aza-2',2'-Difluoro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer. Pharmaceuticals (Basel). 2017 Jul 20;10(3). pii: E65. doi: 10.3390/ph10030065. PubMed PMID: 28726739; PubMed Central PMCID: PMC5620609.