Nagilactone B
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MedKoo CAT#: 564310

CAS#: 19891-51-1

Description: Nagilactone B is a unique selective LXR regulator which suppresses atherosclerosis in apoE-deficient mice via promotion of cholesterol efflux in macrophages.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 720 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-22. Prices are subject to change without notice.

Nagilactone B, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564310
Name: Nagilactone B
CAS#: 19891-51-1
Chemical Formula: C19H24O7
Exact Mass: 364.1522
Molecular Weight: 364.39
Elemental Analysis: C, 62.63; H, 6.64; O, 30.73


Synonym: Nagilactone B

IUPAC/Chemical Name: (1S,2R,3aS,5aS,6R,10bS,10cR)-1,2,6-Trihydroxy-3a,10b-dimethyl-7-(1-methylethyl)-1,2,3,3a,5a,6,10b,10c-octahydro-4H,9H-[2]benzofuro[7,1-fg]isochromene-4,9-dione

InChi Key: AEGWYWSJGKOLGB-ZLNDBNLZSA-N

InChi Code: InChI=1S/C19H24O7/c1-7(2)13-11-8(5-10(21)25-13)19(4)15-14(12(11)22)26-17(24)18(15,3)6-9(20)16(19)23/h5,7,9,12,14-16,20,22-23H,6H2,1-4H3/t9-,12-,14-,15+,16-,18+,19-/m1/s1

SMILES Code: O=C(O1)[C@@]2(C)C[C@@H](O)[C@@H](O)[C@]3(C)C4=CC(OC(C(C)C)=C4[C@@H](O)[C@]1([H])[C@]32[H])=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Gui Y, Yao S, Yan H, Hu L, Yu C, Gao F, Xi C, Li H, Ye Y, Wang Y. A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice. Cardiovasc Res. 2016 Oct;112(1):502-14. doi: 10.1093/cvr/cvw183. Epub 2016 Jul 26. PubMed PMID: 27460841.