AMG-222 tosylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573127

CAS#: 1163719-08-1

Description: AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.

Chemical Structure

AMG-222 tosylate
CAS# 1163719-08-1

Theoretical Analysis

MedKoo Cat#: 573127
Name: AMG-222 tosylate
CAS#: 1163719-08-1
Chemical Formula: C39H47N9O6S
Exact Mass: 769.337
Molecular Weight: 769.92
Elemental Analysis: C, 60.84; H, 6.15; N, 16.37; O, 12.47; S, 4.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AMG-222 tosylate

IUPAC/Chemical Name: 5-((S)-2-((2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)propyl)-N2,N2,N8,N8-tetramethyl-5-(1H-tetrazol-5-yl)-10,11-dihydro-5H-dibenzo[a,d][7]annulene-2,8-dicarboxamide 4-methylbenzenesulfonate


InChi Code: InChI=1S/C32H39N9O3.C7H8O3S/c1-20(34-19-28(42)41-14-6-7-25(41)18-33)17-32(31-35-37-38-36-31)26-12-10-23(29(43)39(2)3)15-21(26)8-9-22-16-24(11-13-27(22)32)30(44)40(4)5;1-6-2-4-7(5-3-6)11(8,9)10/h10-13,15-16,20,25,34H,6-9,14,17,19H2,1-5H3,(H,35,36,37,38);2-5H,1H3,(H,8,9,10)/t20-,25-;/m0./s1

SMILES Code: N#C[C@@H]1CCCN1C(CN[C@@H](C)CC2(C3=NN=NN3)C(C=CC(C(N(C)C)=O)=C4)=C4CCC5=C2C=CC(C(N(C)C)=O)=C5)=O.CC6=CC=C(S(O)(=O)=O)C=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 769.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kiang YH, Cheung E, Stephens PW, Nagapudi K. Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods. J Pharm Sci. 2014 Sep;103(9):2809-2818. doi: 10.1002/jps.23873. Epub 2014 Jan 27. PubMed PMID: 24470123.