WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573127
Description: AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.
MedKoo Cat#: 573127
Name: AMG-222 tosylate
Chemical Formula: C39H47N9O6S
Exact Mass: 769.337
Molecular Weight: 769.92
Elemental Analysis: C, 60.84; H, 6.15; N, 16.37; O, 12.47; S, 4.16
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Synonym: AMG-222 tosylate
IUPAC/Chemical Name: 5-((S)-2-((2-((S)-2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)propyl)-N2,N2,N8,N8-tetramethyl-5-(1H-tetrazol-5-yl)-10,11-dihydro-5H-dibenzo[a,d]annulene-2,8-dicarboxamide 4-methylbenzenesulfonate
InChi Key: BULNWZLJRCOXPR-VMZNWUEUSA-N
InChi Code: InChI=1S/C32H39N9O3.C7H8O3S/c1-20(34-19-28(42)41-14-6-7-25(41)18-33)17-32(31-35-37-38-36-31)26-12-10-23(29(43)39(2)3)15-21(26)8-9-22-16-24(11-13-27(22)32)30(44)40(4)5;1-6-2-4-7(5-3-6)11(8,9)10/h10-13,15-16,20,25,34H,6-9,14,17,19H2,1-5H3,(H,35,36,37,38);2-5H,1H3,(H,8,9,10)/t20-,25-;/m0./s1
SMILES Code: N#C[C@@H]1CCCN1C(CN[C@@H](C)CC2(C3=NN=NN3)C(C=CC(C(N(C)C)=O)=C4)=C4CCC5=C2C=CC(C(N(C)C)=O)=C5)=O.CC6=CC=C(S(O)(=O)=O)C=C6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 769.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kiang YH, Cheung E, Stephens PW, Nagapudi K. Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods. J Pharm Sci. 2014 Sep;103(9):2809-2818. doi: 10.1002/jps.23873. Epub 2014 Jan 27. PubMed PMID: 24470123.