Sabinene | CAS#3387-41-5 | antifungal

Sabinene
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584638

CAS#: 3387-41-5

Description: Sabinene is a bicyclic monoterpene found in a variety of plants that has antifungal and anti-inflammatory properties.

Chemical Structure

Sabinene

CAS# 3387-41-5

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 584638
Name: Sabinene
CAS#: 3387-41-5
Chemical Formula: C10H16
Exact Mass: 136.13
Molecular Weight: 136.240
Elemental Analysis: C, 88.16; H, 11.84

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 240
50mg	USD 400
100mg	USD 630
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Sabinene; NSC 407278

IUPAC/Chemical Name: 4-methylene-1-(1-methylethyl)-bicyclo[3.1.0]hexane

InChi Key: NDVASEGYNIMXJL-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H16/c1-7(2)10-5-4-8(3)9(10)6-10/h7,9H,3-6H2,1-2H3

SMILES Code: CC(C12CCC(C1C2)=C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, DMF, and ethanol

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Sabinene has antifungal and anti-inflammatory properties. It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml). Sabinene prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
In vitro activity:	Sabinene may have potential for therapeutic applications in managing dermatophytosis and inflammatory-related diseases. Sabinene exhibited significant antifungal activity against dermatophytes and Cryptococcus neoformans.Sabinene demonstrated strong anti-inflammatory effects by inhibiting NO production in macrophages stimulated with lipopolysaccharide and interferon gamma. It also exhibited NO scavenging properties and inhibited inducible NO synthase expression. Reference: Food Chem Toxicol. 2013 Dec;62:349-54. https://pubmed.ncbi.nlm.nih.gov/24012643/
In vivo activity:	Sabinene has potential for mitigating muscle atrophy by modulating ROS-mediated MAPK/MuRF-1 pathways, potentially leading to the restoration of muscle fiber size in fasted rats.Sabinene treatment led to a reduction in muscle fiber atrophy and a decrease in the expression of E3 ubiquitin ligase muscle ring-finger protein-1 (MuRF-1) in the gastrocnemius muscle of fasted rats. Reference: Int J Mol Sci. 2019 Oct 8;20(19):4955. https://pubmed.ncbi.nlm.nih.gov/31597276/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	20.0	146.80
	DMSO	20.0	146.80
	Ethanol	20.0	146.80

Preparing Stock Solutions

The following data is based on the product molecular weight 136.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Valente J, Zuzarte M, Gonçalves MJ, Lopes MC, Cavaleiro C, Salgueiro L, Cruz MT. Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil. Food Chem Toxicol. 2013 Dec;62:349-54. doi: 10.1016/j.fct.2013.08.083. Epub 2013 Sep 5. PMID: 24012643. 2. Cao Y, Zhang H, Liu H, Liu W, Zhang R, Xian M, Liu H. Biosynthesis and production of sabinene: current state and perspectives. Appl Microbiol Biotechnol. 2018 Feb;102(4):1535-1544. doi: 10.1007/s00253-017-8695-5. Epub 2017 Dec 20. PMID: 29264773. 3. Ryu Y, Lee D, Jung SH, Lee KJ, Jin H, Kim SJ, Lee HM, Kim B, Won KJ. Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK-MuRF-1 Pathway in Rats. Int J Mol Sci. 2019 Oct 8;20(19):4955. doi: 10.3390/ijms20194955. PMID: 31597276; PMCID: PMC6801606.
In vitro protocol:	1. Valente J, Zuzarte M, Gonçalves MJ, Lopes MC, Cavaleiro C, Salgueiro L, Cruz MT. Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil. Food Chem Toxicol. 2013 Dec;62:349-54. doi: 10.1016/j.fct.2013.08.083. Epub 2013 Sep 5. PMID: 24012643. 2. Cao Y, Zhang H, Liu H, Liu W, Zhang R, Xian M, Liu H. Biosynthesis and production of sabinene: current state and perspectives. Appl Microbiol Biotechnol. 2018 Feb;102(4):1535-1544. doi: 10.1007/s00253-017-8695-5. Epub 2017 Dec 20. PMID: 29264773.
In vivo protocol:	1. Ryu Y, Lee D, Jung SH, Lee KJ, Jin H, Kim SJ, Lee HM, Kim B, Won KJ. Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK-MuRF-1 Pathway in Rats. Int J Mol Sci. 2019 Oct 8;20(19):4955. doi: 10.3390/ijms20194955. PMID: 31597276; PMCID: PMC6801606.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1. Marchini, M., Charvoz, C., Dujourdy, L., et al. Multidimensional analysis of cannabis volatile constituents: Identification of 5,5-dimethyl-1-vinylbicyclo[2.1.1]hexane as a volatile marker of hashish, the resin of Cannabis sativa L. J. Chromatogr. A. 1370, 200-215 (2014).

2. Cao, Y., Zhang, H., Liu, H., et al. Biosynthesis and production of sabinene: Current state and perspectives. Appl. Microbiol. Biotechnol. 102(4), 1535-1544 (2018).

3. Valente, J., Zuzarte, M., Gonçalves, M.J., et al. Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oil. Food Chem. Toxicol. 62, 349-354 (2013).

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