Velnacrine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341616

CAS#: 124027-47-0

Description: Velnacrine is a biochemical.


Chemical Structure

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Velnacrine
CAS# 124027-47-0

Theoretical Analysis

MedKoo Cat#: 341616
Name: Velnacrine
CAS#: 124027-47-0
Chemical Formula: C13H14N2O
Exact Mass: 214.11
Molecular Weight: 214.268
Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Velnacrine.

IUPAC/Chemical Name: 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-

InChi Key: HLVVITIHAZBPKB-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H14N2O/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15)

SMILES Code: OC1CCCC2=NC3=CC=CC=C3C(N)=C21

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 214.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sahoo AK, Dandapat J, Dash UC, Kanhar S. Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease. J Ethnopharmacol. 2018 Apr 6;215:42-73. doi: 10.1016/j.jep.2017.12.015. Epub 2017 Dec 14. Review. PubMed PMID: 29248451.

2: Silva-Herdade AS, Saldanha C. Effects of acetylcholine on an animal mode of inflammation. Clin Hemorheol Microcirc. 2013;53(1-2):209-16. doi: 10.3233/CH-121646. PubMed PMID: 23187452.

3: Qian S, Wo SK, Zuo Z. Pharmacokinetics and brain dispositions of tacrine and its major bioactive monohydroxylated metabolites in rats. J Pharm Biomed Anal. 2012 Mar 5;61:57-63. doi: 10.1016/j.jpba.2011.11.025. Epub 2011 Dec 3. PubMed PMID: 22196801.

4: Carvalho FA, de Almeida JP, Freitas-Santos T, Saldanha C. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. J Membr Biol. 2009 Mar;228(2):89-97. doi: 10.1007/s00232-009-9162-8. Epub 2009 Mar 18. PubMed PMID: 19294450.

5: Lopes de Almeida JP, Carvalho FA, Silva-Herdade AS, Santos-Freitas T, Saldanha C. Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells. Cell Biol Int. 2009 Mar;33(3):268-75. doi: 10.1016/j.cellbi.2008.11.012. Epub 2008 Dec 11. PubMed PMID: 19101643.

6: Carvalho FA, Almeida JP, Fernandes IO, Freitas-Santos T, Saldanha C. Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clin Hemorheol Microcirc. 2008;40(3):207-27. PubMed PMID: 19029645.

7: Almeida JP, Carvalho FA, Freitas T, Saldanha C. Modulation of hemorheological parameters by the erythrocyte redox thiol status. Clin Hemorheol Microcirc. 2008;40(2):99-111. PubMed PMID: 19029635.

8: de Oliveira S, Silva-Herdade AS, Saldanha C. Modulation of erythrocyte deformability by PKC activity. Clin Hemorheol Microcirc. 2008;39(1-4):363-73. PubMed PMID: 18503146.

9: Silva AS, Saldanha C, Martins e Silva J. Effects of velnacrine maleate in the leukocyte-endothelial cell interactions in rat cremaster microcirculatory network. Clin Hemorheol Microcirc. 2007;36(3):235-46. PubMed PMID: 17361025.

10: Sung JH, Hong SS, Ahn SH, Li H, Seo SY, Park CH, Park BS, Chung SJ. Mechanism for increased bioavailability of tacrine in fasted rats. J Pharm Pharmacol. 2006 May;58(5):643-9. PubMed PMID: 16640833.

11: Carvalho FA, Mesquita R, Martins-Silva J, Saldanha C. Acetylcholine and choline effects on erythrocyte nitrite and nitrate levels. J Appl Toxicol. 2004 Nov-Dec;24(6):419-27. PubMed PMID: 15551380.

12: Carvalho FA, Martins-Silva J, Saldanha C. Amperometric measurements of nitric oxide in erythrocytes. Biosens Bioelectron. 2004 Oct 15;20(3):505-8. PubMed PMID: 15494232.

13: Jinghui L, Yingbao Y, Yongcheng L, Zhiliang C, Xiongyu W. [Effects of metabolites of mangrove fungus Xylaria sp. from South China Sea Coast on the activity of acetylcholinesterase in vitro]. Zhong Yao Cai. 2004 Apr;27(4):261-4. Chinese. PubMed PMID: 15307683.

14: Birks J, Wilcock GG. Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748. Review. PubMed PMID: 15106259.

15: Aparicio I, Callejón M, Bello MA, Jiménez JC, Guiraúm A. Spectrofluorimetric determination of velnacrine in human serum and urine. Farmaco. 2003 Dec;58(12):1257-61. PubMed PMID: 14630236.

16: Tabarrini O, Cecchetti V, Temperini A, Filipponi E, Lamperti MG, Fravolini A. Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease. Bioorg Med Chem. 2001 Nov;9(11):2921-8. PubMed PMID: 11597473.

17: Schütz H, Ahrens B, Erdmann F, Weiler G. [Detection of the cholinesterase inhibitor tacrine and its main metabolites]. Arch Kriminol. 2001 May-Jun;207(5-6):154-61. German. PubMed PMID: 11508052.

18: Aparicio I, Callejón M, Jiménez JC, Bello MA, Guiraúm A. Electrochemical oxidation at carbon paste electrode of tacrine and 1-hydroxytacrine and differential pulse voltammetric determination of tacrine in pharmaceuticals and human urine. Analyst. 2000 Nov;125(11):2016-9. PubMed PMID: 11193091.

19: Nordberg A. PET studies and cholinergic therapy in Alzheimer's disease. Rev Neurol (Paris). 1999;155 Suppl 4:S53-63. Review. PubMed PMID: 10637939.

20: Laine K, Palovaara S, Tapanainen P, Manninen P. Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy. Clin Pharmacol Ther. 1999 Dec;66(6):602-8. PubMed PMID: 10613616.