Aloe emodin anthrone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573109

CAS#: 6247-99-0

Description: Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Chemical Structure

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Aloe emodin anthrone
CAS# 6247-99-0
Instruction

Theoretical Analysis

MedKoo Cat#: 573109
Name: Aloe emodin anthrone
CAS#: 6247-99-0
Chemical Formula: C15H12O4
Exact Mass: 256.07
Molecular Weight: 256.260
Elemental Analysis: C, 70.31; H, 4.72; O, 24.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Aloe emodin anthrone

IUPAC/Chemical Name: 9(10H)-Anthracenone, 1,8-dihydroxy-3-(hydroxymethyl)-

InChi Key: AVZIASIVCYCZND-UHFFFAOYSA-N

InChi Code: 1S/C15H12O4/c16-7-8-4-10-6-9-2-1-3-11(17)13(9)15(19)14(10)12(18)5-8/h1-5,16-18H,6-7H2

SMILES Code: C1(c2c(cc(cc2O)CO)Cc2c1c(O)ccc2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 256.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kai M, Hayashi K, Kaida I, Aki H, Yamamoto M. Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa. Biol Pharm Bull. 2002 Dec;25(12):1608-13. PubMed PMID: 12499649.

2: Yagi T, Yamauchi K, Kuwano S. The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion. J Pharm Pharmacol. 1997 Jan;49(1):22-5. PubMed PMID: 9120764.

3: Che QM, Akao T, Hattori M, Kobashi K, Namba T. Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. Planta Med. 1991 Feb;57(1):15-9. PubMed PMID: 2062951.