SW15

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564256

CAS#: NONE

Description: SW15 is a potent HSP27 cross linker which alters dimeric HSP27 and yields sensitization in human lung cancer cells when combined with HSP90 inhibitors or standard anticancer modalities such as irradiation and cytotoxic anticancer drugs.

Chemical Structure

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SW15
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564256
Name: SW15
CAS#: NONE
Chemical Formula: C20H16O4S2
Exact Mass: 384.05
Molecular Weight: 384.460
Elemental Analysis: C, 62.48; H, 4.19; O, 16.65; S, 16.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SW-15; SW 15; SW15

IUPAC/Chemical Name: 1,3-Bis(thiiran-2-ylmethoxy)-9H-xanthen-9-one

InChi Key: HEJFBUFZDGKAEO-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H16O4S2/c21-19-14-3-1-2-4-15(14)20(22)18-16(19)5-11(23-7-12-9-25-12)6-17(18)24-8-13-10-26-13/h1-6,12-13H,7-10H2

SMILES Code: O=C1C2=C(C(C3=C1C=CC=C3)=O)C=C(OCC4SC4)C=C2OCC5SC5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 384.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jans DA, Moll T, Nasmyth K, Jans P. Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells. J Biol Chem. 1995 Jul 21;270(29):17064-7. PubMed PMID: 7615496.

2: Stillman DJ, Dorland S, Yu Y. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics. 1994 Mar;136(3):781-8. PubMed PMID: 8005433; PubMed Central PMCID: PMC1205884.

3: Lydall D, Ammerer G, Nasmyth K. A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription. Genes Dev. 1991 Dec;5(12B):2405-19. PubMed PMID: 1752436.

4: Nasmyth K, Adolf G, Lydall D, Seddon A. The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry. Cell. 1990 Aug 24;62(4):631-47. PubMed PMID: 2167175.

5: Neuhaus D, Nakaseko Y, Nagai K, Klug A. Sequence-specific [1H]NMR resonance assignments and secondary structure identification for 1- and 2-zinc finger constructs from SW15. A hydrophobic core involving four invariant residues. FEBS Lett. 1990 Mar 26;262(2):179-84. PubMed PMID: 2110530.

6: Nasmyth K, Seddon A, Ammerer G. Cell cycle regulation of SW15 is required for mother-cell-specific HO transcription in yeast. Cell. 1987 May 22;49(4):549-58. PubMed PMID: 3552251.