Alifedrine HCl
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573105

CAS#: 72913-80-5 (HCl)

Description: Alifedrine, also known as D13625, is a positive inotropic agent. Alifedrine moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias. Alifedrine has an unusual and useful spectrum of pharmacological activity in that it combines antiarrhythmic activity with an ability to improve cardiac function. Alifedrine in the tested model markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload.

Chemical Structure

img
Alifedrine HCl
CAS# 72913-80-5 (HCl)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 573105
Name: Alifedrine HCl
CAS#: 72913-80-5 (HCl)
Chemical Formula: C18H28ClNO2
Exact Mass: 289.20
Molecular Weight: 325.877
Elemental Analysis: C, 66.34; H, 8.66; Cl, 10.88; N, 4.30; O, 9.82

Price and Availability

Size Price Availability Quantity
1mg USD 150 Ready to ship
5mg USD 450 Ready to ship
10mg USD 750 Ready to ship
25mg USD 1350 Ready to ship
50mg USD 2350 Ready to ship
100mg USD 3850 Ready to ship
Bulk inquiry

Related CAS #: 72913-80-5 (HCl)   78756-61-3 (free base)    

Synonym: Alifedrine; Alifedrine HCl; D 13625; D-13625; D13625

IUPAC/Chemical Name: 1-cyclohexyl-3-(((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)amino)propan-1-one hydrochloride

InChi Key: AKEXDXACYGXMJG-DJKAKHFESA-N

InChi Code: InChI=1S/C18H27NO2.ClH/c1-14(18(21)16-10-6-3-7-11-16)19-13-12-17(20)15-8-4-2-5-9-15;/h3,6-7,10-11,14-15,18-19,21H,2,4-5,8-9,12-13H2,1H3;1H/t14-,18-;/m0./s1

SMILES Code: O=C(C1CCCCC1)CCN[C@@H](C)[C@H](O)C2=CC=CC=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target: Alifedrine, also known as D13625, is a positive inotropic agent.
In vitro activity: TBD
In vivo activity: Acute ischemic left ventricular failure was induced in dogs by coronary embolization with plastic microspheres, resulting in reduced cardiac output (CO), increased left ventricular end-diastolic pressure (LVEDP), pulmonary capillary pressure (PCP), and total peripheral resistance (TPR). Intravenous (i.v.) administration of alifedrine, a beta-adrenergic partial agonist (0.3 mg/kg as bolus and 0.3 mg/kg/h as infusion), significantly improved performance of the failing heart. Thus, alifedrine in this model markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload. Reference: J Cardiovasc Pharmacol. 1989 Jul;14(1):103-8. https://pubmed.ncbi.nlm.nih.gov/2475700/

Preparing Stock Solutions

The following data is based on the product molecular weight 325.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Metzenauer P, Dedecke R, Göbel H, Martorana PA, Stroman F, Szelenyi I. Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure. J Cardiovasc Pharmacol. 1989 Jul;14(1):103-8. doi: 10.1097/00005344-198907000-00018. PMID: 2475700. 2. Wainwright CL, Parratt JR. Alifedrine, a positive inotropic agent that moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias. Eur J Pharmacol. 1988 Mar 15;147(3):373-80. doi: 10.1016/0014-2999(88)90171-9. PMID: 3378563.
In vitro protocol: TBD
In vivo protocol: 1. Metzenauer P, Dedecke R, Göbel H, Martorana PA, Stroman F, Szelenyi I. Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure. J Cardiovasc Pharmacol. 1989 Jul;14(1):103-8. doi: 10.1097/00005344-198907000-00018. PMID: 2475700. 2. Wainwright CL, Parratt JR. Alifedrine, a positive inotropic agent that moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias. Eur J Pharmacol. 1988 Mar 15;147(3):373-80. doi: 10.1016/0014-2999(88)90171-9. PMID: 3378563.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Anand IS, Hughes LO, Whittington JR, Raftery EB. Acute haemodynamic effects of different doses of alifedrine in congestive heart failure. Eur J Clin Pharmacol. 1989;36(4):335-41. PubMed PMID: 2737225.

2: Wan SK, Hoff W, Evans TR. Haemodynamic effects of intravenous and oral alifedrine in patients with cardiac failure. Curr Med Res Opin. 1988;11(4):242-53. PubMed PMID: 3215041.

3: Schanzenbächer P, Riegger G, Liebau G, Hockerts T, Kochsiek K. [Acute hemodynamic effects of alifedrine in patients with heart failure]. Z Kardiol. 1984 Feb;73(2):95-100. German. PubMed PMID: 6719988.

4: Wainwright CL, Parratt JR. Alifedrine, a positive inotropic agent that moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias. Eur J Pharmacol. 1988 Mar 15;147(3):373-80. PubMed PMID: 3378563.

5: Metzenauer P, Dedecke R, Göbel H, Martorana PA, Stroman F, Szelenyi I. Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure. J Cardiovasc Pharmacol. 1989 Jul;14(1):103-8. PubMed PMID: 2475700.

6: Engel J, Bekel H, Heiliger D, Schaumlöffel E. [14C-labeling of alifedrine hydrochloride, a new positive inotropic compound]. Arch Pharm (Weinheim). 1985 May;318(5):465-7. German. PubMed PMID: 4026541.

7: Bickel E, Engel J, Klingler KH. [Syntheses of 14C-1-erythro-norephedrine and its N-substitution products 14C-oxyfedrine and 14C-D 13,625]. Arzneimittelforschung. 1983;33(9):1213-5. German. PubMed PMID: 6685500.

8: Colucci WS, Wright RF, Braunwald E. New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2. N Engl J Med. 1986 Feb 6;314(6):349-58. Review. PubMed PMID: 2418353.