N-Ethyl-3-piperidyl benzilate

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MedKoo CAT#: 581484

CAS#: 3567-12-2

Description: N-Ethyl-3-piperidyl benzilate (JB-318) is discontinued (DEA controlled susbtance). It is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate.


Price and Availability

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Pricing updated 2020-10-31. Prices are subject to change without notice.

N-Ethyl-3-piperidyl benzilate (JB-318) is discontinued (DEA controlled susbtance).


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 581484
Name: N-Ethyl-3-piperidyl benzilate
CAS#: 3567-12-2
Chemical Formula: C21H25NO3
Exact Mass: 339.1834
Molecular Weight: 339.435
Elemental Analysis: C, 74.31; H, 7.42; N, 4.13; O, 14.14


Synonym: N-Ethyl-3-piperidyl benzilate;

IUPAC/Chemical Name: Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 1-ethyl-3-piperidinyl ester (9CI)

InChi Key: OJYOTLHNSMYONM-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25NO3/c1-2-22-15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,2,9,14-16H2,1H3

SMILES Code: O=C(OC1CN(CC)CCC1)C(C2=CC=CC=C2)(O)C3=CC=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Nishiyama S, Tsukada H, Sato K, Kakiuchi T, Ohba H, Harada N, Takahashi K. Evaluation of PET ligands (+)N-[(11)C]ethyl-3-piperidyl benzilate and (+)N-[(11)C]propyl-3-piperidyl benzilate for muscarinic cholinergic receptors: a PET study with microdialysis in comparison with (+)N-[(11)C]methyl-3-piperidyl benzilate in the conscious monkey brain. Synapse. 2001 Jun 1;40(3):159-69. PubMed PMID: 11304753.

2: Chen CH, Abdel-Monem MM, Krick TP. Metabolism of N-ethyl-3-piperidyl benzilate in rats. J Pharm Sci. 1977 Jul;66(7):931-5. PubMed PMID: 886453.

3: HEULLY F, DORNIER R, FONDER A, BAUZON M, MESSENET M. [1st clinical trials of a new parasym-patholytic: the bromomethylate of N-ethyl-3-piperidyl benzilate (or compound AN 1111 or Piptal) in the treatment of peptic ulcer]. Rev Med Nancy. 1961 Jun;86:602-12. French. PubMed PMID: 13713987.

4: CHEN JY. Pharmacologic properties of N-ethyl-3-piperidyl benzilate methobromide (JB-323), a potent antispasmodic agent. J Pharmacol Exp Ther. 1954 Sep;112(1):64-72. PubMed PMID: 13192610.