N-Benzylpiperazine

MedKoo is just lunch a new version of website, please use the Search function if you cannot find our product. We apologize for the inconvenience.xs

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581482

CAS#: 2759-28-6

Description: Benzylpiperazine (BZP) is discontinued (DEA controlled substance). It is a recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity and seizures.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-02-17. Prices are subject to change without notice.

Benzylpiperazine (BZP) is discontinued (DEA controlled substance).


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 581482
Name: N-Benzylpiperazine
CAS#: 2759-28-6
Chemical Formula: C11H16N2
Exact Mass: 176.1313
Molecular Weight: 176.26
Elemental Analysis: C, 74.96; H, 9.15; N, 15.89


Synonym: N-Benzylpiperazine; 1-Benzylpiperazine; BZP;

IUPAC/Chemical Name: 1-benzylpiperazine

InChi Key: IQXXEPZFOOTTBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2

SMILES Code: C(N1CCNCC1)c2ccccc2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Bajda M, Łątka K, Hebda M, Jończyk J, Malawska B. Novel carbamate derivatives as selective butyrylcholinesterase inhibitors. Bioorg Chem. 2018 Aug;78:29-38. doi: 10.1016/j.bioorg.2018.03.003. Epub 2018 Mar 3. PubMed PMID: 29529519.

2: Roh J, Karabanovich G, Vlčková H, Carazo A, Němeček J, Sychra P, Valášková L, Pavliš O, Stolaříková J, Klimešová V, Vávrová K, Pávek P, Hrabálek A. Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents. Bioorg Med Chem. 2017 Oct 15;25(20):5468-5476. doi: 10.1016/j.bmc.2017.08.010. Epub 2017 Aug 8. PubMed PMID: 28835350.

3: Castillo-Hernández JC, Velázquez-Moyado JA, Reyes-Ramírez A, Ramírez-López EG, González-Andrade M, Navarrete A. Effect of N-Benzylpiperazine, Its Metabolite N-Benzylethylenediamine, and Its Disubstituted Analogue N,N'-Dibenzylpiperazine on the Acquisition, Formation, and Consolidation of Memory in Mice. Pharmacology. 2017;99(5-6):268-274. doi: 10.1159/000457905. Epub 2017 Feb 21. PubMed PMID: 28219076.

4: Dias da Silva D, Silva MJ, Moreira P, Martins MJ, Valente MJ, Carvalho F, Bastos ML, Carmo H. In vitro hepatotoxicity of 'Legal X': the combination of 1-benzylpiperazine (BZP) and 1-(m-trifluoromethylphenyl)piperazine (TFMPP) triggers oxidative stress, mitochondrial impairment and apoptosis. Arch Toxicol. 2017 Mar;91(3):1413-1430. doi: 10.1007/s00204-016-1777-9. Epub 2016 Jun 29. PubMed PMID: 27358233.

5: Lee H, Wang GY, Curley LE, Kydd RR, Kirk IJ, Russell BR. Investigation of the effects of 'piperazine-containing party pills' and dexamphetamine on interhemispheric communication using electroencephalography. Psychopharmacology (Berl). 2016 Aug;233(15-16):2869-77. doi: 10.1007/s00213-016-4335-5. Epub 2016 Jun 11. PubMed PMID: 27289365.

6: Persona K, Polus A, Góralska J, Gruca A, Dembińska-Kieć A, Piekoszewski W. An In Vitro Study of the Neurotoxic Effects of N-Benzylpiperazine: A Designer Drug of Abuse. Neurotox Res. 2016 May;29(4):558-68. doi: 10.1007/s12640-016-9604-x. Epub 2016 Feb 9. PubMed PMID: 26861955; PubMed Central PMCID: PMC4820481.

7: Wenholz DS, Luong S, Philp M, Forbes SL, Stuart BH, Drummer OH, Fu S. A study to model the post-mortem stability of 4-MMC, MDMA and BZP in putrefying remains. Forensic Sci Int. 2016 Aug;265:54-60. doi: 10.1016/j.forsciint.2016.01.006. Epub 2016 Jan 16. PubMed PMID: 26829335.

8: Arbo MD, Silva R, Barbosa DJ, Dias da Silva D, Silva SP, Teixeira JP, Bastos ML, Carmo H. In vitro neurotoxicity evaluation of piperazine designer drugs in differentiated human neuroblastoma SH-SY5Y cells. J Appl Toxicol. 2016 Jan;36(1):121-30. doi: 10.1002/jat.3153. Epub 2015 Apr 20. PubMed PMID: 25900438.

9: Dias-da-Silva D, Arbo MD, Valente MJ, Bastos ML, Carmo H. Hepatotoxicity of piperazine designer drugs: Comparison of different in vitro models. Toxicol In Vitro. 2015 Aug;29(5):987-96. doi: 10.1016/j.tiv.2015.04.001. Epub 2015 Apr 9. PubMed PMID: 25863214.

10: Wilkins C, Sweetsur P, Parker K. The impact of the prohibition of benzylpiperazine (BZP) "legal highs" on the availability, price and strength of BZP in New Zealand. Drug Alcohol Depend. 2014 Nov 1;144:47-52. doi: 10.1016/j.drugalcdep.2014.07.011. Epub 2014 Aug 1. PubMed PMID: 25213143.

11: Arbo MD, Silva R, Barbosa DJ, da Silva DD, Rossato LG, Bastos Mde L, Carmo H. Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment. Toxicol Lett. 2014 Aug 17;229(1):178-89. doi: 10.1016/j.toxlet.2014.06.031. Epub 2014 Jun 23. PubMed PMID: 24968061.

12: Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies. Eur J Med Chem. 2014 Jul 23;82:426-38. doi: 10.1016/j.ejmech.2014.05.066. Epub 2014 May 27. PubMed PMID: 24929293.

13: Musshoff F, Hottmann L, Hess C, Madea B. ["Legal highs" from the German internet--"bath salt drugs" on the rise]. Arch Kriminol. 2013 Sep-Oct;232(3-4):91-103. German. PubMed PMID: 24358620.

14: Monteiro MS, Bastos Mde L, Guedes de Pinho P, Carvalho M. Update on 1-benzylpiperazine (BZP) party pills. Arch Toxicol. 2013 Jun;87(6):929-47. doi: 10.1007/s00204-013-1057-x. Epub 2013 May 18. Review. PubMed PMID: 23685794.

15: Johnson RD, Botch-Jones SR. The stability of four designer drugs: MDPV, mephedrone, BZP and TFMPP in three biological matrices under various storage conditions. J Anal Toxicol. 2013 Mar;37(2):51-5. doi: 10.1093/jat/bks138. Epub 2013 Jan 16. PubMed PMID: 23325764.

16: Wilkins C, Sweetsur P. The impact of the prohibition of benzylpiperazine (BZP) 'legal highs' on the prevalence of BZP, new legal highs and other drug use in New Zealand. Drug Alcohol Depend. 2013 Jan 1;127(1-3):72-80. doi: 10.1016/j.drugalcdep.2012.06.014. Epub 2012 Jul 20. PubMed PMID: 22819869.

17: World Health Organization. WHO expert committee on drug dependence. World Health Organ Tech Rep Ser. 2012;(973):1-26. PubMed PMID: 24547667.

18: Arbo MD, Bastos ML, Carmo HF. Piperazine compounds as drugs of abuse. Drug Alcohol Depend. 2012 May 1;122(3):174-85. doi: 10.1016/j.drugalcdep.2011.10.007. Epub 2011 Nov 8. Review. PubMed PMID: 22071119.

19: Berney-Meyer L, Putt T, Schollum J, Walker R. Nephrotoxicity of recreational party drugs. Nephrology (Carlton). 2012 Feb;17(2):99-103. doi: 10.1111/j.1440-1797.2011.01537.x. Review. PubMed PMID: 22066519.

20: Chai Y, Sun H, Pan Y, Sun C. N-centered odd-electron ions formation from collision-induced dissociation of electrospray ionization generated even-electron ions: single electron transfer via ion/neutral complex in the fragmentation of protonated N,N'-dibenzylpiperazines and protonated N-benzylpiperazines. J Am Soc Mass Spectrom. 2011 Sep;22(9):1526-33. doi: 10.1007/s13361-011-0176-y. Epub 2011 Jun 22. PubMed PMID: 21953256.