20-HETE | CAS# 79551-86-3 | Lipid Mediator

20-HETE
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564216

CAS#: 79551-86-3

Description: 20-HETE is a lipid mediator which activates the transcription of ACE via NFkB translocation and promoter binding. This causes detrimental effects in cerebral circulation, and modulating KCa3.1 channels.

Chemical Structure

20-HETE

CAS# 79551-86-3

Instruction

Theoretical Analysis

MedKoo Cat#: 564216
Name: 20-HETE
CAS#: 79551-86-3
Chemical Formula: C20H32O3
Exact Mass: 320.24
Molecular Weight: 320.470
Elemental Analysis: C, 74.96; H, 10.07; O, 14.98

Price and Availability

Size	Price	Availability
25µg	USD 450	2 Weeks
50µg	USD 750	2 Weeks
100µg	USD 1250	2 Weeks
500µg	USD 3650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 20-Hydroxyeicosatetraeonic acid; 20 Hydroxyeicosatetraeonic acid; 20Hydroxyeicosatetraeonic acid; 20HETE; 20 HETE; 20-HETE

IUPAC/Chemical Name: (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid

InChi Key: NNDIXBJHNLFJJP-DTLRTWKJSA-N

InChi Code: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-

SMILES Code: OCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

Appearance: A solution in ethanol (100ug/ml)

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Certificate of Analysis:

View CoA: current batch, Lot# C22M02C16

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 320.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Lu L, Wang M, Wei X, Li W. 20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. Front Aging Neurosci. 2018 Jul 16;10:207. doi: 10.3389/fnagi.2018.00207. eCollection 2018. Erratum in: Front Aging Neurosci. 2018 Aug 20;10:239. PubMed PMID: 30061822; PubMed Central PMCID: PMC6054934.

2: Rocic P, Schwartzman ML. 20-HETE in the regulation of vascular and cardiac function. Pharmacol Ther. 2018 Jul 23. pii: S0163-7258(18)30123-2. doi: 10.1016/j.pharmthera.2018.07.004. [Epub ahead of print] Review. PubMed PMID: 30048707.

3: Zhang X, El Demerdash N, Falck JR, Munnuri S, Koehler RC, Yang ZJ. The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury. Prostaglandins Other Lipid Mediat. 2018 Jul;137:63-68. doi: 10.1016/j.prostaglandins.2018.07.001. Epub 2018 Jul 6. Review. PubMed PMID: 30041768; PubMed Central PMCID: PMC6092952.

4: Zhang C, Booz GW, Yu Q, He X, Wang S, Fan F. Conflicting roles of 20-HETE in hypertension and renal end organ damage. Eur J Pharmacol. 2018 Aug 15;833:190-200. doi: 10.1016/j.ejphar.2018.06.010. Epub 2018 Jun 7. Review. PubMed PMID: 29886242; PubMed Central PMCID: PMC6057804.

5: Costa TJ, Ceravolo GS, Echem C, Hashimoto CM, Costa BP, Santos-Eichler RA, Oliveira MA, Jiménez-Altayó F, Akamine EH, Dantas AP, Carvalho MHC. Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension. Front Physiol. 2018 May 8;9:490. doi: 10.3389/fphys.2018.00490. eCollection 2018. PubMed PMID: 29867542; PubMed Central PMCID: PMC5952044.

6: Roman RJ, Fan F. 20-HETE: Hypertension and Beyond. Hypertension. 2018 Jul;72(1):12-18. doi: 10.1161/HYPERTENSIONAHA.118.10269. Epub 2018 May 14. Review. PubMed PMID: 29760152; PubMed Central PMCID: PMC6002933.

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