Albizziin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573095

CAS#: 585-23-9

Description: Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification. This is a non-stereospecific analogue at the 2nd carbon.


Chemical Structure

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Albizziin
CAS# 585-23-9

Theoretical Analysis

MedKoo Cat#: 573095
Name: Albizziin
CAS#: 585-23-9
Chemical Formula: C4H9N3O3
Exact Mass: 147.06
Molecular Weight: 147.130
Elemental Analysis: C, 32.65; H, 6.17; N, 28.56; O, 32.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Albizziin

IUPAC/Chemical Name: 3-((Aminocarbonyl)amino)alanine

InChi Key: LYKIYOKXXWRCHS-REOHCLBHSA-N

InChi Code: 1S/C4H9N3O3/c5-2(1-3(8)9)7-4(6)10/h2H,1,5H2,(H,8,9)(H3,6,7,10)/t2-/m0/s1

SMILES Code: N(C(=O)N)[C@@H](CC(=O)O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wei C, Andrulis IL. Overexpression of asparagine synthetase in albizziin-resistant murine diploid embryonic stem cells. Somat Cell Mol Genet. 1993 Jul;19(4):321-30. PubMed PMID: 8105542.

2: Andrulis IL, Argonza R, Cairney AE. Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin. Somat Cell Mol Genet. 1990 Jan;16(1):59-65. PubMed PMID: 1968681.

3: Andrulis IL, Evans-Blackler S, Siminovitch L. Characterization of single step albizziin-resistant Chinese hamster ovary cell lines with elevated levels of asparagine synthetase activity. J Biol Chem. 1985 Jun 25;260(12):7523-7. PubMed PMID: 2860112.

4: Andrulis IL, Duff C, Evans-Blackler S, Worton R, Siminovitch L. Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells. Mol Cell Biol. 1983 Mar;3(3):391-8. PubMed PMID: 6133214; PubMed Central PMCID: PMC368547.