WAY103

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564196

CAS#: NONE

Description: WAY103 is a very late adhesion molecule 4 (VLA-4) antagonist. It inhibits VLA-4/VCAM-1 ligation as a means of modulating eosinophil functions beyond its action on cell adhesion and migration.

Chemical Structure

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WAY103
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564196
Name: WAY103
CAS#: NONE
Chemical Formula: C22H29N5O7S2
Exact Mass: 539.15
Molecular Weight: 539.620
Elemental Analysis: C, 48.97; H, 5.42; N, 12.98; O, 20.75; S, 11.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: WAY-103; WAY 103; WAY103

IUPAC/Chemical Name: (2S)-3-(4-Dimethylcarbamoyloxyphenyl)-2-{[(4R)-5,5-dimethyl-3-(1-methyl-1H-pyrazole-4 sulfonyl)thiazolidine-4-carbonyl]amino}propionic acid

InChi Key: IZHMSLJUKTYUPC-ZWKOTPCHSA-N

InChi Code: InChI=1S/C22H29N5O7S2/c1-22(2)18(27(13-35-22)36(32,33)16-11-23-26(5)12-16)19(28)24-17(20(29)30)10-14-6-8-15(9-7-14)34-21(31)25(3)4/h6-9,11-12,17-18H,10,13H2,1-5H3,(H,24,28)(H,29,30)/t17-,18+/m0/s1

SMILES Code: O=C(O)[C@@H](NC([C@H]1N(S(=O)(C2=CN(C)N=C2)=O)CSC1(C)C)=O)CC3=CC=C(OC(N(C)C)=O)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 539.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sedgwick JB, Jansen KJ, Kennedy JD, Kita H, Busse WW. Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions. J Allergy Clin Immunol. 2005 Oct;116(4):812-9. Epub 2005 Aug 24. PubMed PMID: 16210055.