WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564196
CAS#: NONE
Description: WAY103 is a very late adhesion molecule 4 (VLA-4) antagonist. It inhibits VLA-4/VCAM-1 ligation as a means of modulating eosinophil functions beyond its action on cell adhesion and migration.
MedKoo Cat#: 564196
Name: WAY103
CAS#: NONE
Chemical Formula: C22H29N5O7S2
Exact Mass: 539.1508
Molecular Weight: 539.62
Elemental Analysis: C, 48.97; H, 5.42; N, 12.98; O, 20.75; S, 11.88
This product is not in stock, which may be available by custom synthesis.
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Synonym: WAY-103; WAY 103; WAY103
IUPAC/Chemical Name: (2S)-3-(4-Dimethylcarbamoyloxyphenyl)-2-{[(4R)-5,5-dimethyl-3-(1-methyl-1H-pyrazole-4 sulfonyl)thiazolidine-4-carbonyl]amino}propionic acid
InChi Key: IZHMSLJUKTYUPC-ZWKOTPCHSA-N
InChi Code: InChI=1S/C22H29N5O7S2/c1-22(2)18(27(13-35-22)36(32,33)16-11-23-26(5)12-16)19(28)24-17(20(29)30)10-14-6-8-15(9-7-14)34-21(31)25(3)4/h6-9,11-12,17-18H,10,13H2,1-5H3,(H,24,28)(H,29,30)/t17-,18+/m0/s1
SMILES Code: O=C(O)[C@@H](NC([C@H]1N(S(=O)(C2=CN(C)N=C2)=O)CSC1(C)C)=O)CC3=CC=C(OC(N(C)C)=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 539.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sedgwick JB, Jansen KJ, Kennedy JD, Kita H, Busse WW. Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions. J Allergy Clin Immunol. 2005 Oct;116(4):812-9. Epub 2005 Aug 24. PubMed PMID: 16210055.