Alpha-CF3-TMC

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564138

CAS#: NONE

Description: alpha-CF3-TMC is an inhibitor of JAK2 and STAT5 phosphorylation in response to interleukin-3, without altering STAT5 mobility in SDS-PAGE.


Chemical Structure

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Alpha-CF3-TMC
CAS# NONE

Theoretical Analysis

MedKoo Cat#: 564138
Name: Alpha-CF3-TMC
CAS#: NONE
Chemical Formula: C20H19F3O5
Exact Mass: 396.1185
Molecular Weight: 396.36
Elemental Analysis: C, 60.61; H, 4.83; F, 14.38; O, 20.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: alpha-CF3-TMC; alphaCF3TMC; alpha CF3 TMC; alphaCF3-TMC; alpha-CF3TMC

IUPAC/Chemical Name: alpha-Trifluoromethyl-2',3,4,4'-tetramethoxychalcone

InChi Key: FZGGGRGCLANZMB-DHDCSXOGSA-N

InChi Code: InChI=1S/C20H19F3O5/c1-25-13-6-7-14(17(11-13)27-3)19(24)15(20(21,22)23)9-12-5-8-16(26-2)18(10-12)28-4/h5-11H,1-4H3/b15-9-

SMILES Code: O=C(C1=CC=C(OC)C=C1OC)/C(C(F)(F)F)=C/C2=CC=C(OC)C(OC)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 396.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jobst B, Weigl J, Michl C, Vivarelli F, Pinz S, Amslinger S, Rascle A. Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2',3,4,4'-tetramethoxychalcones α-Br-TMC and α-CF3-TMC. Biol Chem. 2016 Nov 1;397(11):1187-1204. doi: 10.1515/hsz-2016-0148. PubMed PMID: 27341558.