Alpha-Br-TMC

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564137

CAS#: NONE

Description: Alpha-Br-TMC is a JAK2/STAT5 inhibitor.

Chemical Structure

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Alpha-Br-TMC
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 564137
Name: Alpha-Br-TMC
CAS#: NONE
Chemical Formula: C19H19BrO5
Exact Mass: 406.04
Molecular Weight: 407.260
Elemental Analysis: C, 56.04; H, 4.70; Br, 19.62; O, 19.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: alpha-Br-TMC; alphaBrTMC; alpha Br TMC; alpha-BrTMC; alpha Br-TMC

IUPAC/Chemical Name: alpha-Bromo-2',3,4,4'-tetramethoxychalcone

InChi Key: CQUJXQCEXQXZBD-DHDCSXOGSA-N

InChi Code: InChI=1S/C19H19BrO5/c1-22-13-6-7-14(17(11-13)24-3)19(21)15(20)9-12-5-8-16(23-2)18(10-12)25-4/h5-11H,1-4H3/b15-9-

SMILES Code: O=C(C1=CC=C(OC)C=C1OC)/C(Br)=C/C2=CC=C(OC)C(OC)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 407.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jobst B, Weigl J, Michl C, Vivarelli F, Pinz S, Amslinger S, Rascle A. Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2',3,4,4'-tetramethoxychalcones α-Br-TMC and α-CF3-TMC. Biol Chem. 2016 Nov 1;397(11):1187-1204. doi: 10.1515/hsz-2016-0148. PubMed PMID: 27341558.

2: Pinz S, Unser S, Brueggemann S, Besl E, Al-Rifai N, Petkes H, Amslinger S, Rascle A. The synthetic α-bromo-2',3,4,4'-tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway. PLoS One. 2014 Mar 3;9(3):e90275. doi: 10.1371/journal.pone.0090275. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105845. PubMed PMID: 24595334; PubMed Central PMCID: PMC3940872.