N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos
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MedKoo CAT#: 573021

CAS#: 1817735-42-4

Description: N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos is a PEG Linker.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 440 2 Weeks
250mg USD 740 2 Weeks
500mg USD 1130 2 Weeks
1g USD 1440 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-08. Prices are subject to change without notice.

N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 573021
Name: N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos
CAS#: 1817735-42-4
Chemical Formula: C27H39NO11S2
Exact Mass: 617.1965
Molecular Weight: 617.73
Elemental Analysis: C, 52.50; H, 6.36; N, 2.27; O, 28.49; S, 10.38


Synonym: N-Tos-N-(t-butoxycarbonyl)-aminoxy-PEG4-Tos

IUPAC/Chemical Name: 2,2-dimethyl-4-oxo-5-tosyl-3,6,9,12,15-pentaoxa-5-azaheptadecan-17-yl 4-methylbenzenesulfonate

InChi Key: NXRDQGCADASLGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H39NO11S2/c1-22-6-10-24(11-7-22)40(30,31)28(26(29)39-27(3,4)5)37-20-18-35-16-14-34-15-17-36-19-21-38-41(32,33)25-12-8-23(2)9-13-25/h6-13H,14-21H2,1-5H3

SMILES Code: O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCON(S(=O)(C2=CC=C(C)C=C2)=O)C(OC(C)(C)C)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.

2: Harrison E, Coulter JA, Dixon D. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker. Nanomedicine (Lond). 2016 Apr;11(7):851-65. Review. PubMed PMID: 27021417.

3: Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). pii: E1190. doi: 10.3390/molecules22071190. PubMed PMID: 28714870; PubMed Central PMCID: PMC5776016.

4: Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. PubMed PMID: 7578129.

5: Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. doi:10.1016/j.jconrel.2016.02.017. Epub 2016 Feb 8. PubMed PMID: 26869546.