Mafenide Hydrochloride
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MedKoo CAT#: 564091

CAS#: 138-37-4 (HCl)

Description: Mafenide Hydrochloride is an antibiotic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa.


Chemical Structure

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Mafenide Hydrochloride
CAS# 138-37-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 564091
Name: Mafenide Hydrochloride
CAS#: 138-37-4 (HCl)
Chemical Formula: C7H11ClN2O2S
Exact Mass: 222.023
Molecular Weight: 222.69
Elemental Analysis: C, 37.76; H, 4.98; Cl, 15.92; N, 12.58; O, 14.37; S, 14.40

Price and Availability

Size Price Availability Quantity
25.0g USD 245.0 2 Weeks
250.0g USD 640.0 2 Weeks
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Related CAS #: 138-39-6 (free base)   12001-72-8 (propionate)   138-37-4 (HCl)   138-39-6 (acetate)  

Synonym: Marfanil; 4-Aminomethylbenzenesulfonamide hydrochloride; Mafenide Hydrochloride

IUPAC/Chemical Name: 4-(Aminomethyl)benzenesulfonamide hydrochloride

InChi Key: SIACJRVYIPXFKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H10N2O2S.ClH/c8-5-6-1-3-7(4-2-6)12(9,10)11;/h1-4H,5,8H2,(H2,9,10,11);1H

SMILES Code: O=S(C1=CC=C(CN)C=C1)(N)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 222.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mendelson JA. Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue. Prehosp Disaster Med. 2001 Jul-Sep;16(3):172-4. Review. PubMed PMID: 11875802.

2: Mendelson JA. The management of burns under conditions of limited resources using topical aqueous sulfamylon (mafenide) hydrochloride spray. J Burn Care Rehabil. 1997 May-Jun;18(3):238-44. PubMed PMID: 9169948.

3: Holder IA. Wet disc testing of mafenide hydrochloride, chlorhexidine gluconate, and triple antibiotic solution against bacteria isolated from burn wounds. J Burn Care Rehabil. 1990 Jul-Aug;11(4):301-4. PubMed PMID: 2401684.

4: Mendelson JA, Pratt HJ, Amato JJ, Lieberman MK, Hamm TE, Gruber RP, Brinkley FB, Heitkamp DH, Healy MJ. Mafenide hydrochloride and mafenide acetate in spray and ointment forms as topical therapy of C. perfringens contaminated massive wounds: experimental study. J Trauma. 1970 Dec;10(12):1132-44. PubMed PMID: 4320694.

5: Skulan TW, Hoppe JO. Preliminary observations on the toxicity of the hydrochloride and acetate salts of mafenide (sulfamylon r). Life Sci. 1966 Dec;5(24):2279-82. PubMed PMID: 5972782.