4-Methylethcathinone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581413

CAS#: 1225617-18-4

Description: 4-Methylethcathinone, or 4-MEC, is discontinued (DEA controlled substance). Due to its similarity to mephedrone, it is thought to be a stimulant and entactogen drug of the phenethylamine, amphetamine, and cathinone chemical classes.


Chemical Structure

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4-Methylethcathinone
CAS# 1225617-18-4

Theoretical Analysis

MedKoo Cat#: 581413
Name: 4-Methylethcathinone
CAS#: 1225617-18-4
Chemical Formula: C12H17NO
Exact Mass: 191.131
Molecular Weight: 191.27
Elemental Analysis: C, 75.35; H, 8.96; N, 7.32; O, 8.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 4-Methylethcathinone; 4-MEC

IUPAC/Chemical Name: 2-(ethylamino)-1-(p-tolyl)propan-1-one

InChi Key: ZOXZWYWOECCBSH-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H17NO/c1-4-13-10(3)12(14)11-7-5-9(2)6-8-11/h5-8,10,13H,4H2,1-3H3

SMILES Code: CCNC(C)C(=O)c1ccc(C)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 191.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Larabi IA, Martin M, Etting I, Penot P, Fabresse N, Alvarez JC. Drug-facilitated sexual assault (DFSA) involving 4-methylethcathinone (4-MEC), 3,4-Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis. Drug Test Anal. 2018 Mar 10. doi: 10.1002/dta.2377. [Epub ahead of print] PubMed PMID: 29524346.

2: Skultety L, Frycak P, Qiu C, Smuts J, Shear-Laude L, Lemr K, Mao JX, Kroll P, Schug KA, Szewczak A, Vaught C, Lurie I, Havlicek V. Resolution of isomeric new designer stimulants using gas chromatography - Vacuum ultraviolet spectroscopy and theoretical computations. Anal Chim Acta. 2017 Jun 8;971:55-67. doi: 10.1016/j.aca.2017.03.023. Epub 2017 Mar 22. PubMed PMID: 28456284.

3: Maas A, Sydow K, Madea B, Hess C. Separation of ortho, meta and para isomers of methylmethcathinone (MMC) and methylethcathinone (MEC) using LC-ESI-MS/MS: Application to forensic serum samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 15;1051:118-125. doi: 10.1016/j.jchromb.2017.01.046. Epub 2017 Feb 1. PubMed PMID: 28262446.

4: Miller B, Kim J, Concheiro M. Stability of synthetic cathinones in oral fluid samples. Forensic Sci Int. 2017 May;274:13-21. doi: 10.1016/j.forsciint.2016.11.034. Epub 2016 Dec 1. PubMed PMID: 27916403.

5: Alvarez JC, Etting I, Abe E, Villa A, Fabresse N. Identification and quantification of 4-methylethcathinone (4-MEC) and 3,4-methylenedioxypyrovalerone (MDPV) in hair by LC-MS/MS after chronic administration. Forensic Sci Int. 2017 Jan;270:39-45. doi: 10.1016/j.forsciint.2016.11.028. Epub 2016 Nov 24. PubMed PMID: 27914279.

6: Molnár B, Fodor B, Csámpai A, Hidvégi E, Molnár-Perl I. Structure-related related new approach in the gas chromatography/mass spectrometry analysis of cathinone type synthetic drugs. J Chromatogr A. 2016 Dec 16;1477:70-75. doi: 10.1016/j.chroma.2016.11.033. Epub 2016 Nov 22. PubMed PMID: 27912966.

7: Huskinson SL, Naylor JE, Townsend EA, Rowlett JK, Blough BE, Freeman KB. Self-administration and behavioral economics of second-generation synthetic cathinones in male rats. Psychopharmacology (Berl). 2017 Feb;234(4):589-598. doi: 10.1007/s00213-016-4492-6. Epub 2016 Nov 28. PubMed PMID: 27896377; PubMed Central PMCID: PMC5266647.

8: Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Swanson T, Johnson RA, Janowsky A. Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release. J Pharmacol Exp Ther. 2017 Jan;360(1):33-47. Epub 2016 Oct 31. PubMed PMID: 27799294; PubMed Central PMCID: PMC5193076.

9: Glicksberg L, Bryand K, Kerrigan S. Identification and quantification of synthetic cathinones in blood and urine using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 1;1035:91-103. doi: 10.1016/j.jchromb.2016.09.027. Epub 2016 Sep 20. PubMed PMID: 27697731.

10: Silva B, Fernandes C, Tiritan ME, Pinto MM, Valente MJ, Carvalho M, de Pinho PG, Remião F. Chiral enantioresolution of cathinone derivatives present in "legal highs", and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV). Forensic Toxicol. 2016;34:372-385. Epub 2016 Jun 13. PubMed PMID: 27594923; PubMed Central PMCID: PMC4988346.

11: Smith PR, Cole R, Hamilton S, West K, Morley SR, Maskell PD. Reporting Two Fatalities Associated with the Use of 4-Methylethcathinone (4-MEC) and a Review of the Literature. J Anal Toxicol. 2016 Sep;40(7):553-60. doi: 10.1093/jat/bkw061. Epub 2016 Jul 11. PubMed PMID: 27405367.

12: Valente MJ, Araújo AM, Bastos Mde L, Fernandes E, Carvalho F, Guedes de Pinho P, Carvalho M. Editor's Highlight: Characterization of Hepatotoxicity Mechanisms Triggered by Designer Cathinone Drugs (β-Keto Amphetamines). Toxicol Sci. 2016 Sep;153(1):89-102. doi: 10.1093/toxsci/kfw105. Epub 2016 Jun 2. PubMed PMID: 27255387.

13: Mercolini L, Protti M, Catapano MC, Rudge J, Sberna AE. LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples. J Pharm Biomed Anal. 2016 May 10;123:186-94. doi: 10.1016/j.jpba.2016.02.015. Epub 2016 Feb 16. PubMed PMID: 26905673.

14: Odoardi S, Romolo FS, Strano-Rossi S. A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015. Forensic Sci Int. 2016 Aug;265:116-20. doi: 10.1016/j.forsciint.2016.01.037. Epub 2016 Feb 1. PubMed PMID: 26874736.

15: Salomone A, Gazzilli G, Di Corcia D, Gerace E, Vincenti M. Determination of cathinones and other stimulant, psychedelic, and dissociative designer drugs in real hair samples. Anal Bioanal Chem. 2016 Mar;408(8):2035-42. doi: 10.1007/s00216-015-9247-4. Epub 2015 Dec 17. PubMed PMID: 26680593.

16: Adamowicz P, Gieroń J, Gil D, Lechowicz W, Skulska A, Tokarczyk B. The prevalence of new psychoactive substances in biological material - a three-year review of casework in Poland. Drug Test Anal. 2016 Jan;8(1):63-70. doi: 10.1002/dta.1924. Epub 2015 Dec 14. Review. PubMed PMID: 26666629.

17: Xu P, Qiu Y, Zhang Y, Βai Y, Xu P, Liu Y, Kim JH, Shen HW. The Effects of 4-Methylethcathinone on Conditioned Place Preference, Locomotor Sensitization, and Anxiety-Like Behavior: A Comparison with Methamphetamine. Int J Neuropsychopharmacol. 2016 Apr 20;19(4). pii: pyv120. doi: 10.1093/ijnp/pyv120. Print 2016 Apr. PubMed PMID: 26612552; PubMed Central PMCID: PMC4851266.

18: Kerrigan S, Savage M, Cavazos C, Bella P. Thermal Degradation of Synthetic Cathinones: Implications for Forensic Toxicology. J Anal Toxicol. 2016 Jan-Feb;40(1):1-11. doi: 10.1093/jat/bkv099. Epub 2015 Aug 20. PubMed PMID: 26294756.

19: Zuway KY, Smith JP, Foster CW, Kapur N, Banks CE, Sutcliffe OB. Detection and quantification of new psychoactive substances (NPSs) within the evolved "legal high" product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD). Analyst. 2015 Sep 21;140(18):6283-94. doi: 10.1039/c5an01106j. PubMed PMID: 26244169.

20: Acton WJ, Lanza M, Agarwal B, Jürschik S, Sulzer P, Breiev K, Jordan A, Hartungen E, Hanel G, Märk L, Mayhew CA, Märk TD. Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer. Int J Mass Spectrom. 2014 Mar 1;360:28-38. PubMed PMID: 25844048; PubMed Central PMCID: PMC4375562.