3-Fluoromethcathinone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581411

CAS#: 1049677-77-1

Description: 3-FMC is discontinued (DEA controlled substance). It is a stimulant of the phenethylamine, amphetamine and cathinone chemical classes. It is a structural isomer of flephedrone (4-fluoromethcathinone).


Chemical Structure

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3-Fluoromethcathinone
CAS# 1049677-77-1

Theoretical Analysis

MedKoo Cat#: 581411
Name: 3-Fluoromethcathinone
CAS#: 1049677-77-1
Chemical Formula: C10H12FNO
Exact Mass: 181.0903
Molecular Weight: 181.21
Elemental Analysis: C, 66.28; H, 6.68; F, 10.48; N, 7.73; O, 8.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 3-Fluoromethcathinone; 3'-Fluoromethcathinone; 3-FMC

IUPAC/Chemical Name: 1-(3-fluorophenyl)-2-(methylamino)propan-1-one

InChi Key: PQIBROLLUQSNQI-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H12FNO/c1-7(12-2)10(13)8-4-3-5-9(11)6-8/h3-7,12H,1-2H3

SMILES Code: CNC(C)C(=O)c1cccc(F)c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 181.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Siedlecka-Kroplewska K, Wrońska A, Stasiłojć G, Kmieć Z. The Designer Drug 3-Fluoromethcathinone Induces Oxidative Stress and Activates Autophagy in HT22 Neuronal Cells. Neurotox Res. 2018 Oct;34(3):388-400. doi: 10.1007/s12640-018-9898-y. Epub 2018 Apr 14. PubMed PMID: 29656349.

2: Glicksberg L, Kerrigan S. Stability of Synthetic Cathinones in Urine. J Anal Toxicol. 2018 Mar 1;42(2):77-87. doi: 10.1093/jat/bkx091. PubMed PMID: 29194549.

3: Glicksberg L, Kerrigan S. Stability of Synthetic Cathinones in Blood. J Anal Toxicol. 2017 Nov 1;41(9):711-719. doi: 10.1093/jat/bkx071. PubMed PMID: 28977581.

4: Glicksberg L, Bryand K, Kerrigan S. Identification and quantification of synthetic cathinones in blood and urine using liquid chromatography-quadrupole/time of flight (LC-Q/TOF) mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 1;1035:91-103. doi: 10.1016/j.jchromb.2016.09.027. Epub 2016 Sep 20. PubMed PMID: 27697731.

5: Odoardi S, Romolo FS, Strano-Rossi S. A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015. Forensic Sci Int. 2016 Aug;265:116-20. doi: 10.1016/j.forsciint.2016.01.037. Epub 2016 Feb 1. PubMed PMID: 26874736.

6: Gatch MB, Rutledge MA, Forster MJ. Discriminative and locomotor effects of five synthetic cathinones in rats and mice. Psychopharmacology (Berl). 2015 Apr;232(7):1197-205. doi: 10.1007/s00213-014-3755-3. Epub 2014 Oct 5. PubMed PMID: 25281225; PubMed Central PMCID: PMC4361374.

7: Siedlecka-Kroplewska K, Szczerba A, Lipinska A, Slebioda T, Kmiec Z. 3-Fluoromethcathinone, a structural analog of mephedrone, inhibits growth and induces cell cycle arrest in HT22 mouse hippocampal cells. J Physiol Pharmacol. 2014 Apr;65(2):241-6. PubMed PMID: 24781733.

8: Simmler LD, Rickli A, Hoener MC, Liechti ME. Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology. 2014 Apr;79:152-60. doi: 10.1016/j.neuropharm.2013.11.008. Epub 2013 Nov 22. PubMed PMID: 24275046.

9: Al-Saffar Y, Stephanson NN, Beck O. Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:112-20. doi: 10.1016/j.jchromb.2013.04.043. Epub 2013 May 7. PubMed PMID: 23727875.

10: Marinetti LJ, Antonides HM. Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results. J Anal Toxicol. 2013 Apr;37(3):135-46. doi: 10.1093/jat/bks136. Epub 2013 Jan 29. PubMed PMID: 23361867.

11: Marusich JA, Grant KR, Blough BE, Wiley JL. Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice. Neurotoxicology. 2012 Oct;33(5):1305-13. doi: 10.1016/j.neuro.2012.08.003. Epub 2012 Aug 23. PubMed PMID: 22922498; PubMed Central PMCID: PMC3475178.

12: Meyer MR, Vollmar C, Schwaninger AE, Wolf E, Maurer HH. New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine. J Mass Spectrom. 2012 Feb;47(2):253-62. doi: 10.1002/jms.2960. PubMed PMID: 22359337.

13: Davis S, Rands-Trevor K, Boyd S, Edirisinghe M. The characterisation of two halogenated cathinone analogues: 3,5-difluoromethcathinone and 3,5-dichloromethcathinone. Forensic Sci Int. 2012 Apr 10;217(1-3):139-45. doi: 10.1016/j.forsciint.2011.10.042. Epub 2011 Nov 15. PubMed PMID: 22088945.

14: Pawlik E, Plässer G, Mahler H, Daldrup T. Studies on the phase I metabolism of the new designer drug 3-fluoromethcathinone using rabbit liver slices. Int J Legal Med. 2012 Mar;126(2):231-40. doi: 10.1007/s00414-011-0601-6. Epub 2011 Jul 23. Erratum in: Int J Legal Med. 2012 Mar;126(2):241-2. PubMed PMID: 21785905.

15: Archer RP. Fluoromethcathinone, a new substance of abuse. Forensic Sci Int. 2009 Mar 10;185(1-3):10-20. doi: 10.1016/j.forsciint.2008.11.013. Epub 2009 Feb 4. PubMed PMID: 19195800.