DBO-83
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 589593

CAS#: 195211-53-1

Description: DBO-83 is an agonist of nicotinic acetylcholine receptors (nAChRs) with antinociceptive and anti-amnesic activities.

Chemical Structure

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DBO-83
CAS# 195211-53-1
Instruction

Theoretical Analysis

MedKoo Cat#: 589593
Name: DBO-83
CAS#: 195211-53-1
Chemical Formula: C10H15Cl3N4
Exact Mass: 296.04
Molecular Weight: 297.608
Elemental Analysis: C, 40.36; H, 5.08; Cl, 35.73; N, 18.83

Price and Availability

Size Price Availability Quantity
1mg USD 210
5mg USD 400
10mg USD 655
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Synonym: DBO-83

IUPAC/Chemical Name: 3-(6-chloro-3-pyridazinyl)-3,8-diazabicyclo[3.2.1]octane, dihydrochloride

InChi Key: FMBGHZXNKMHVDT-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H13ClN4.2ClH/c11-9-3-4-10(14-13-9)15-5-7-1-2-8(6-15)12-7;;/h3-4,7-8,12H,1-2,5-6H2;2*1H

SMILES Code: ClC1=NN=C(N2CC(N3)CCC3C2)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Barlocco, D., Cignarella, G., Tondi, D., et al. Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity, and modeling. J. Med. Chem. 41(5), 674-681 (1998).

2. Ghelardini, C., Galeotti, N., Barlocco, D., et al. Antinociceptive profile of the new nicotinic agonist DBO-83. Drug Dev. Res. 40(3), 251-258 (1997).

3. Ghelardini, C., Galeotti, N., Giuliani, F., et al. Antiamnesic activity of the nicotinic agonist DBO-83 in mice. Drug Dev. Res. 45(2), 45-51 (1998).