Protogracillin
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MedKoo CAT#: 584592

CAS#: 54848-30-5

Description: Protogracillin is a steroid saponin originally isolated from T. terrestris. It is cytotoxic to K562 cells.


Chemical Structure

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Protogracillin
CAS# 54848-30-5

Theoretical Analysis

MedKoo Cat#: 584592
Name: Protogracillin
CAS#: 54848-30-5
Chemical Formula: C51H84O23
Exact Mass: 1,064.54
Molecular Weight: 1,065.210
Elemental Analysis: C, 57.51; H, 7.95; O, 34.55

Price and Availability

Size Price Availability Quantity
1mg USD 240
5mg USD 560
10mg USD 925
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Synonym: Protogracillin

IUPAC/Chemical Name: (3beta,22R,25R)-26-(beta-D-glucopyranosyloxy)-22-hydroxyfurost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranoside

InChi Key: GMCGZPQYTRHQRU-DKWQWWTLSA-N

InChi Code: InChI=1S/C51H84O23/c1-20(19-66-45-40(62)38(60)34(56)29(16-52)69-45)8-13-51(65)21(2)32-28(74-51)15-27-25-7-6-23-14-24(9-11-49(23,4)26(25)10-12-50(27,32)5)68-48-44(73-46-41(63)37(59)33(55)22(3)67-46)43(36(58)31(18-54)71-48)72-47-42(64)39(61)35(57)30(17-53)70-47/h6,20-22,24-48,52-65H,7-19H2,1-5H3/t20-,21+,22+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36-,37-,38+,39+,40-,41-,42-,43+,44-,45-,46+,47+,48-,49+,50+,51-/m1/s1

SMILES Code: O[C@H]([C@@H](CO)O1)[C@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@H](O[C@H]3[C@@H]([C@@H]([C@H]([C@H](C)O3)O)O)O)[C@@H]1O[C@H]4CC[C@]5(C)[C@@]6([H])CC[C@]7(C)[C@]8([H])[C@@]([H])(O[C@@](CC[C@@H](C)CO[C@H]9[C@@H]([C@H]([C@@H]([C@@H](CO)O9)O)O)O)(O)[C@H]8C)C[C@@]7([H])[C@]6([H])CC=C5C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,065.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Tomova, M., Gyulemetova, R., Zarkova, S., et al. Steroidal saponins from Tribulus terrestris L. with a stimulating action on the sexual functions. 1st Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. 3(1), 298-302 (1982).

2. Hu, K., Dong, A.-J., Yao, X.-S., et al. Antineoplastic steroidal saponins from rhizomes of DIoscorea collettii var. Hypoglauca. Stud. Plant Sci. 6, 220-229 (1999).